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https://www.sciencedirect.com/science/article/pii/S0168365917308258
Targeting of drugs deep into nasal mucosa is the utmost requirement of targeted nasal drug delivery to brain. Nasal drops and traditional sprays are unable to deposit drug in olfactory epithelium. These traditional devices are useless for targeting brain through olfactory pathway.Author: Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zhai
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.slideshare.net/kawii/nasal-drug-delivery-system-41893460
Nov 22, 2014 · INTRODUCTION Administration of drug through nasal route is referred as Nasal drug delivery system. Nasal route is an alternative to invasive administrations and provides a direct access to the systemic circulation. Intranasal Medication administration offers a …
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The concentration of drug, dose, and volume of dose administered are all important factors that can affect nasal drug delivery to the brain. Nasal drug absorption increases as the concentration of drug increases at the site of administration.
https://www.ncbi.nlm.nih.gov/pubmed/28887135
Dec 28, 2017 · Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route. Novel DDSs such as nanoparticles (NPs), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (CNS).Author: Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zhai
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