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https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The published experimental data in scientific journals does support that different formulation approaches using mucoadhesive compounds, absorption enhancers, and specialized reagents can increase the efficiency of drug delivery to the brain via the nasal route.
https://www.ncbi.nlm.nih.gov/pubmed/29277310
Feb 15, 2018 · One novel approach to address this challenge is to administer drugs intranasally to noninvasively bypass the blood-brain barrier. The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves.Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.nature.com/articles/s41541-020-0172-y
Mar 24, 2020 · Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice Skip to main content Thank you for visiting nature.com.Author: Hiroki Takeuchi
http://mysticpharmaceuticals.com/nose-to-brain-delivery/
Mystic offers patient-centric delivery systems for systemic intranasal, nose-to-brain, ophthalmic, sublingual, dermal and oral delivery. Our delivery platforms and integration services provides a custom optimized delivery system in combination with your drug or biologic to meet your technical product and market requirements.
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects.
https://www.researchgate.net/publication/339098080_Nose-to-Brain_Delivery
Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties ...
https://www.futurity.org/nasal-spray-brain-cancer-1859772/
While nasal brain drug delivery is a huge step forward, it isn’t yet possible to target a drug to a specific area. Chen’s targeted ultrasound technique is addressing that problem.
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