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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732751/
The present study demonstrates that intranasal delivery of BDNF, CNTF, EPO, and NT-4 in adult rats resulted in substantial concentrations of these neurotrophic factors widely throughout the brain and cervical spinal cord. Comparable delivery was seen for CNTF, EPO, and NT-4.Author: Sandra R. Alcalá-Barraza, Michael S. Lee, Leah R. Hanson, Abby A. McDonald, William H. Frey, Linda K...
https://www.ncbi.nlm.nih.gov/pubmed/19807216
Intranasal delivery of 70 microg [(125)I]-radiolabeled BDNF, CNTF, NT-4, or erythropoietin (EPO) resulted in 0.1-1.0 nM neurotrophin concentrations within 25 min in brain parenchyma. In addition, not only did these neurotrophic factors reach the CNS, they were present in sufficient concentrations to activate the prosurvival PI3Kinase/Akt ...Author: Sandra R. Alcalá-Barraza, Michael S. Lee, Leah R. Hanson, Abby A. McDonald, William H. Frey, Linda K...
https://www.tandfonline.com/doi/abs/10.3109/10611860903318134
Jun 19, 2013 · In vitro experiments have demonstrated that neurotrophic factors such as brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), and neurotrophin-4/5 (NT-4/5) can promote neuronal survival. However, delivery to the injured CNS is difficult as these large protein molecules do not efficiently cross the blood–brain barrier.Author: Sandra R. Alcalá-Barraza, Michael S. Lee, Leah R. Hanson, Abby A. McDonald, William H. Frey, Linda K...
https://experts.umn.edu/en/publications/intranasal-delivery-of-neurotrophic-factors-bdnf-cntf-epo-and-nt-
Intranasal delivery of 70 μg [125 I]-radiolabeled BDNF, CNTF, NT-4, or erythropoietin (EPO) resulted in 0.1-1.0nM neurotrophin concentrations within 25min in brain parenchyma. In addition, not only did these neurotrophic factors reach the CNS, they were present in sufficient concentrations to activate the prosurvival PI3Kinase/Akt pathway ...Author: Sandra R. Alcalá-Barraza, Michael S. Lee, Leah R. Hanson, Abby A. McDonald, William H. Frey, Linda K...
https://www.nature.com/articles/s41598-019-55294-5
Dec 18, 2019 · Focused ultrasound-enhanced intranasal (IN + FUS) delivery is a noninvasive approach that utilizes the olfactory pathway to administer pharmacological agents directly to the brain, allowing for a ...Author: Robin Ji, Morgan Smith, Yusuke Niimi, Maria E. Karakatsani, Maria F. Murillo, Vernice Jackson-Lewis,...
https://www.sciencedirect.com/science/article/pii/S0361923018303678
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.nature.com/articles/srep28599
Jun 27, 2016 · The objective of this study was to unveil the potential mechanism of focused ultrasound (FUS)-enhanced intranasal (IN) brain drug delivery and assess its …Author: Hong Chen, Georgiana Zong Xin Yang, Hoheteberhan Getachew, Camilo Acosta, Carlos Jose Sierra Sánchez...
https://www.researchgate.net/publication/26874302_Intranasal_delivery_of_neurotrophic_factors_BDNF_CNTF_EPO_and_NT-4_to_the_CNS
Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS Article (PDF Available) in Journal of Drug Targeting 18(3):179-90 · October …
https://repository.library.northeastern.edu/files/neu:1726/fulltext.pdf
Intranasal Delivery of GDNF for the Treatment of Parkinson’s Disease Thesis Presented By Mattia M. Migliore To ... non-invasive strategy for delivering therapeutic proteins and neurotrophic factors such as GDNF to the brain for the treatment of central nervous system disorders.
https://www.researchgate.net/publication/338019991_Focused_ultrasound_enhanced_intranasal_delivery_of_brain_derived_neurotrophic_factor_produces_neurorestorative_effects_in_a_Parkinson's_disease_mouse_model
PDF Focused ultrasound-enhanced intranasal (IN + FUS) delivery is a noninvasive approach that utilizes the olfactory pathway to administer... Find, read and cite all the research you need on ...
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