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http://jpet.aspetjournals.org/content/301/1/391
Apr 01, 2002 · The shape of the plasma profile for nasal delivery of the chitosan-morphine formulation was similar to the one obtained for the slow i.v. administration of morphine. Furthermore, the metabolite profile obtained after the nasal administration of the chitosan-morphine nasal formulation was essentially identical to the one obtained for morphine administered by the intravenous route.Author: L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, S. S. Da...
https://www.ncbi.nlm.nih.gov/pubmed/11907197
The levels of both morphine-6-glucuronide and morphine-3-glucuronide were only about 25% of that found after oral administration of morphine. It is concluded that a properly designed nasal morphine formulation (such as one with chitosan) can result in a non-injectable opioid product capable of offering patients rapid and efficient pain relief. PMID: 11907197 [Indexed for MEDLINE] Publication Types: …Author: L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, S. S. Da...
https://www.researchgate.net/publication/11457494_Intranasal_delivery_of_morphine
Intranasal Delivery of Morphine 399 Aspden TJ, Mason JDT, Jones NS, Lowe J, Skaugrud O, and Illum L (1997a) Chitosan as a nasal delivery system: the effect of chitosan solutions on the in vitro
http://cosmas-damian.co.uk/1/morphine391%5b1%5d.pdf
for nasal delivery of the chitosan-morphine formulation was similar to the one obtained for the slow i.v. administration of morphine. Furthermore, the metabolite profile obtained after the nasal administration of the chitosan-morphine nasal formu-lation was essentially identical to the one obtained for morphine administered by the intravenous route.
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.598.3550
CiteSeerX — Intranasal delivery of morphine CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10 % compared with intravenous administration.
https://www.researchgate.net/publication/277450427_Intranasal_Delivery_of_Morphine
Download Citation Intranasal Delivery of Morphine Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% ...
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