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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Using the intranasal delivery system, researchers have reversed neurodegeneration and rescued memory in a transgenic mouse model of Alzheimer's disease. Intranasal insulin-like growth factor-I, deferoxamine, and erythropoietin have been shown …Author: Leah R Hanson, William H Frey, William H Frey
https://www.alzforum.org/therapeutics/nasal-insulin
Intranasal insulin appeared safe in a subsequent four-month course of 20 or 40 IUs of intranasal insulin or placebo given to a larger group of 104 people with aMCI or mild to moderate AD. Called SNIFF-120, this single-center study reported some preservation of cognition in younger participants and some preservation of function.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal administration is a method of delivering therapeutic agents to the central nervous system (CNS). It is non-invasive and allows large molecules that do not cross the blood-brain barrier access to the CNS. Drugs are directly targeted to the CNS with intranasal delivery, reducing systemic exposure and thus unwanted systemic side effects 1.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.lostfalco.com/intranasal-insulin/
Intranasal insulin halts the progression of Alzhiemer’s disease and enhances cognition in humans. Take 10IU after breakfast and 10IU after dinner. Intranasal insulin improved memory, caregiver-rated functional ability, and general cognition in Alzheimer’s Disease patients …
https://www.in-pharmatechnologist.com/Article/2004/12/13/Intranasal-delivery-of-insulin-shows-promise
Dec 13, 2004 · The total dose of intranasal insulin spray ranged from 25 to 100 International Units. Preliminary results indicate that the intranasal insulin was well absorbed and that there was partial suppression of the postprandial glucose elevation in the two hours after a standard breakfast, similar to that seen with subcutaneous insulin.
https://www.diabeticsweekly.com/is-intranasal-insulin-therapy-safe/
In this case, insulin is administered. Therapy is integral for people with Type 1 diabetes. And, for some people with diabetes with Type 2 diabetes, too. In most cases, insulin is injected into the body. Injection pens, pumps, and patches are some of the ways diabetics take insulin. But, an intranasal avenue may be a less invasive way to ...
https://www.sciencedirect.com/science/article/pii/S0304394019306706
Intranasal insulin has already been approved for use in humans in clinical trials, including in AD and PD [10,11]. The advantages of intranasal delivery of insulin, including direct targeting to the brain and minimization of systemic side effects or hypoglycemia, have been treated extensively elsewhere [24,25]. The use of an intranasal delivery ...Author: Jared M. Fine, Benjamin M. Stroebel, Katherine A. Faltesek, Kaoru Terai, Lucas Haase, Kristin E. Knu...
https://www.alzdiscovery.org/cognitive-vitality/ratings/intranasal-insulin
Intranasal insulin is a method to increase brain insulin levels by administering insulin with a spray device through the nasal cavity. Short-term clinical studies suggest that intranasal insulin may improve some aspects of cognitive functions, though results varied depending on different factors such as …
https://www.researchgate.net/publication/233403463_Intranasal_delivery_of_insulin_via_the_olfactory_nerve_pathway
In an investigation into the pathways by which intranasal administration delivers insulin to the CNS, this study has focused on the direct delivery of insulin from the olfactory mucosa to the ...
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