Nasal Delivery Of Apomorphine

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(PDF) Intranasal apomorphine. Nastech Pharmaceutical

    https://www.researchgate.net/publication/8552424_Intranasal_apomorphine_Nastech_Pharmaceutical
    Intranasal apomorphine. Nastech Pharmaceutical. ... limiting factors for nasal drug delivery since it severely . limits the time allowed for dr ug absorption to occur and .

US20020165249A1 - Nasal delivery of apomorphine - Google ...

    https://patents.google.com/patent/US20020165249A1/en
    Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically ...Author: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Rome...

US6436950B1 - Nasal delivery of apomorphine - Google Patents

    https://patents.google.com/patent/US6436950B1/en
    Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal. Nasally administered compositions for treating male erectile dysfunction in a mammal are also provided which include a therapeutically ...Author: Raja G. Achari, Shamim Ahmed, Charanjit R. Behl, Jorge C. deMeireles, Tianquing Liu, Vincent D. Rome...

Challenges and trends in apomorphine drug delivery systems ...

    https://www.sciencedirect.com/science/article/pii/S1818087617306189
    The quick onset of action and the ease of administration make nasal apomorphine delivery a viable option used for ‘rescue’ therapy. 5.2.4. Transdermal delivery. Transdermal drug delivery possesses similar benefits as nasal delivery, which favors apomorphine absorption.Author: Nrupa Borkar, Huiling Mu, René Holm

Preactivated thiomers for intranasal delivery of ...

    https://www.sciencedirect.com/science/article/pii/S093964111630532X
    Preactivated thiomers for intranasal delivery of apomorphine: In vitro and in vivo evaluation. ... Therefore, PAA 250-cys-2MNA with high degree of preactivation could be considered as promising excipient for nasal delivery of apomorphine. Acknowledgments.Author: Kesinee Netsomboon, Kesinee Netsomboon, Alexandra Partenhauser, Julia Rohrer, Nadine Elli Sündermann...

Preactivated thiomers for intranasal delivery of ...

    https://www.ncbi.nlm.nih.gov/pubmed/27615996
    Sep 08, 2016 · Preactivated thiomers for intranasal delivery of apomorphine: in vitro and in vivo evaluation. ... and 80.1, 81.6 and 87% (high degree), respectively. Apomorphine permeation across porcine nasal mucosa in the presence of PAA100-cys-2MNA, PAA250-cys-2MNA and PAA450-cys-2MNA with high degree of preactivation were 3.1-, 4.4- and 4.1-fold, while 2 ...Author: Kesinee Netsomboon, Kesinee Netsomboon, Alexandra Partenhauser, Julia Rohrer, Nadine Elli Sündermann...

Apomorphine Nasal Powder in the Treatment of Parkinson's ...

    https://clinicaltrials.gov/ct2/show/NCT00346827
    Apomorphine Nasal Powder in the Treatment of Parkinson's Disease "Off" Periods. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Preactivated thiomers for intranasal delivery of ...

    https://www.researchgate.net/publication/308036663_Preactivated_thiomers_for_intranasal_delivery_of_apomorphine_In_vitro_and_in_vivo_evaluation
    The purpose of this study was to synthesize preactivated thiomers with different degree of preactivation and to evaluate their potential as novel excipient for nasal apomorphine administration.

Pre-activated Thiomer For Nasal Delivery Of Apomorphine ...

    https://www.omicsonline.org/proceedings/preactivated-thiomer-for-nasal-delivery-of-apomorphine-synthesis-and-in-vitro-evaluation-37468.html
    Pre-activated thiomer for nasal delivery of Apomorphine: Synthesis and in vitro evaluation Pharma Middle East. Kesinee Netsomboon, Flavia Laffleur, Alexandra …Author: Kesinee Netsomboon Flavia Laffleur Alex, ra Partenhauser Felix Prufert, Andreas BernkopSchnurch

Nasal delivery of apomorphine - Patent - Europe PMC

    http://europepmc.org/patents/PAT/US2002165249
    Intranasal delivery methods and compositions for the delivery of dopamine receptor agonists are provided which are effective for the amelioration of erectile dysfunction in a mammal without causing substantial intolerable adverse side effects to the mammal.

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