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https://www.researchgate.net/profile/Amnon_Sintov/publication/266211157_Intranasal_Delivery_of_Two_Benzodiazepines_Midazolam_and_Diazepam_by_a_Microemulsion_System/links/574c10cb08ae7dff1bcfe907/Intranasal-Delivery-of-Two-Benzodiazepines-Midazolam-and-Diazepam-by-a-Microemulsion-System.pdf
Intranasal Delivery of Two Benzodiazepines, Midazolam and Diazepam, by a Microemulsion System 181. vulsions can be used only in children and in a few cases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
https://www.neurologylive.com/clinical-focus/intranasal-diazepam-valtoco-fda-approved-for-seizure-clusters
Jan 13, 2020 · The US FDA has approved intranasal diazepam (Valtoco; Neurelis) for the treatment of acute, intermittent, stereotypic episodes of frequent seizure activity, otherwise known as seizure clusters or acute repetitive seizures. 1 The drug, which is a schedule IV controlled substance, is the first intranasal rescue formulation approved for patients age 6 and older.
https://www.drugs.com/history/valtoco.html
Diazepam Nasal Spray Demonstrates Comparable Bioavailability to Diazepam Rectal Gel in Pharmacokinetic Study: Jun 22, 2011: Particle Sciences Develops Proprietary Nasal Delivery Formulation Used in Neurelis' Recently Announced Successful Phase I Pharmacokinetic Study of NRL-01 (intranasal diazepam) See Also. Valtoco (diazepam) Consumer Information.
VALTOCO ® (diazepam nasal spray) is a prescription medicine used for the short-term rescue treatment of seizure clusters (also known as “acute repetitive seizures”) in patients 6 years of age and older. VALTOCO is not a replacement for daily antiepileptic drugs (AEDs). VALTOCO nasal spray is available in 5 mg, 10 mg, 15 mg, and 20 mg doses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674633/
Feb 21, 2015 · Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles. ... One of them is administration of drugs via nasal route, bypassing the BBB. Diazepam, being lipophilic in nature, rapidly permeates across the membranes and shows fast onset of action; however, it redistributes in the body tissues resulting in decreased serum levels quickly. ...Author: Deepak Sharma, Rakesh Kumar Sharma, Navneet Sharma, Reema Gabrani, Sanjeev K. Sharma, Javed Ali, Shw...
https://www.drugs.com/newdrugs/fda-approves-valtoco-diazepam-nasal-seizure-rescue-5141.html
“The FDA approval of diazepam nasal spray is a significant advancement for the epilepsy community.” Enrique Carrazana, MD, Chief Scientific Officer for Neurelis, notes that Valtoco was generally safe and well tolerated during clinical studies. The most common adverse reactions (at least 4%) were somnolence, headache, and nasal discomfort.
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