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https://en.wikipedia.org/wiki/Nasal_administration
Nasal administration is a route of administration in which drugs are insufflated through the nose.It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects.Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually ...
https://www.researchgate.net/publication/6717417_Nasal_Delivery_of_Antimigraine_Drugs_Clinical_Rationale_and_Evidence_Base
The nasal delivery of anti-migraine drugs can represent an attractive alternative to the oral route via fast absorption from the nasal mucosa, avoidance of the first-pass effect and rapid onset of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846483/
Absorption of drug at the olfactory region of nose provides potential for drugs to be directly delivered to the CNS. However, one of the problems associated with nasal delivery is lower retention time of solution in nasal cavity (15 min) resulting in lower bioavailability.
https://headachejournal.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1526-4610.2006.00603.x
Oct 27, 2006 · The intranasal route of administration for antimigraine drugs offers many theoretical and practical advantages. A drug that is administered intranasally is absorbed by the highly vascular mucous membranes of the nose, which allows for rapid delivery of un‐metabolized drug …Author: Alan Rapoport, Paul Winner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · The guidance primarily addresses in vitro testing of nasal sprays and pressurized aerosols for local action. The reference to in vivo performance is limited to the recommendation of minimizing the fraction of respirable particles below 9 μm in order to avoid lung …Author: Per Gisle Djupesland
https://www.sciencedirect.com/science/article/pii/S0378517319303862
Different types of formulations and delivery systems are studied for the nose to brain drug delivery. Readers can go through available scientific compilation of different intranasal drug delivery systems (Warnken et al., 2016).The systems not only deliver small synthetic drugs, but also large molecules, such as protein or peptides, hormones, and stem cells, to obtain a therapeutic benefit.Author: Bappaditya Chatterjee, Bapi Gorain, Keithanchali Mohananaidu, Pinaki Sengupta, Uttam Kumar Mandal, H...
https://www.drugs.com/dosage/sumatriptan.html
Oct 15, 2019 · Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 28 Feb 2020), Cerner Multum™ (updated 2 Mar 2020), …7.8/10
https://www.ijpsonline.com/articles/nanoemulsion-based-intranasal-delivery-of-antimigraine-drugs-for-nose-to-brain-targeting.html
Nanoemulsion based intranasal delivery of antimigraine drugs for nose to brain targeting, RS Bhanushali1, MM Gatne2, RV Gaikwad3, AN Bajaj1, MA Morde1Author: RS Bhanushali, MM Gatne, RV Gaikwad, AN Bajaj, MA Morde
https://www.sciencedirect.com/science/article/pii/S0149291809004779
(Clin Ther. 2009;31:2954987) 2009 Excerpta Medica Inc. Key words: systematic review, nasal drug delivery, pharmacokinetics, opioids, benzodiazepines, antimigraine drugs. INTRODUCTION Interest in the development of advanced drug-delivery routes, such as …Author: Nicole M.L. Veldhorst-Janssen, Audrey A.A. Fiddelers, Paul-Hugo M. van der Kuy, Cees Neef, Marco A.E...
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