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https://www.sciencedirect.com/science/article/abs/pii/S0010854518301127
Non-viral, multifunctional nanoparticles for gene delivery. • Their proficiency in crossing the biological barriers. • Applications in gene therapy of cancers, infectious and brain dysfunctional diseases. • In vitro and in vivo toxicity assessments of multifunctional nanoparticles. • Present challenges and gaps between in vitro and clinical research.Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://www.tandfonline.com/doi/abs/10.1517/17425240903241796
Sep 28, 2009 · Although these alternative vectors have shown promise, degradable nanoparticles are the only non-viral vectors that can provide a targeted intracellular delivery …Author: Andrew J Ditto, Parth N Shah, Yang H Yun
https://www.sciencedirect.com/science/article/pii/S0010854518301127
4. Multifunctional nanoparticles for gene delivery. Despite the potentially higher biosafety of non-viral vectors in gene delivery, the therapeutic effect of single-functional non-viral vectors is far from satisfactory. In order to manage the challenges associated with non-viral vectors, multifunctional nanoparticles have been introduced.Author: Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang, Ken-Tye Yong
https://www.researchgate.net/publication/26837587_Non-viral_gene_delivery_using_nanoparticles
Although these alternative vectors have shown promise, degradable nanoparticles are the only non-viral vectors that can provide a targeted intracellular delivery with controlled release properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597487/
Non-viral vectors. In gene therapy, the research focus has shifted towards the development of non-viral gene delivery vectors. In most cases, these vectors are relatively simple to synthesize, and devoid, to a large extent, of the health risks that are associated with their viral counterparts 1.The other major advantage of non-viral vectors is the absence of limitation on the size and number ...Author: Indrajit Roy, Michal K. Stachowiak, Earl J. Bergey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Calcium phosphate nanoparticles, routinely used for in vitro transfection, have been investigated as a powerful non-viral gene delivery . These nanoparticles alone, or in combination with other vectors (viral or nonviral), show good gene delivery properties especially when incorporated in the colloidal particulate systems [ 58 ].Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
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