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https://www.sciencedirect.com/science/article/pii/S0022354915506692
Zonula occludens toxin, a recently discovered protein elaborated by Vibrio cholerae, provided tools to gain more insights on the pathophysiology of the regulation of intestinal permeability through the paracellular pathway and to develop alternative approaches for the oral delivery of drugs and macromolecules normally not absorbed through the intestine.Author: Alessio Fasano
https://link.springer.com/article/10.1007/s12257-009-3058-4
Mar 18, 2010 · Strategies for oral delivery of macromolecule drugs. Abstract. Advances in biotechnology, gene manipulation, and protein engineering for macromolecule drugs, such as insulin, parathyroid hormone (PTH), calcitonin, human growth hormone, erythropoietin (EPO), and peptide YY (PYY) allow commercial production in large scale for diverse therapeutic uses.Author: Jin Woo Park, Sang Kyoon Kim, Taslim Ahmed Al-Hilal, Ok Cheol Jeon, Hyun Tae Moon, Youngro Byun
http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · Researchers are studying oral delivery approaches for macromolecular drugs that have better patient acceptance and adherence, more convenient dosing, and an improved therapeutic profile. Before patients can benefit, researchers must address the technology gaps that have prevented development of more oral macromolecule dosage forms.
https://www.researchgate.net/publication/260681021_Novel_strategies_for_the_buccal_delivery_of_macromolecules
Dosage forms for buccal delivery of macromolecules A review of the literature on macromolecule-loaded dosage forms reveals that conventional dosage forms such as tablets hav e in the
https://www.sciencedirect.com/science/article/pii/S0169409X16300278
Although novel approaches such as buccal delivery are under clinical investigation, it remains to be seen if the systemic delivery of orally applied macromolecules above 5000 Da, notably insulin, can be achieved sufficiently reproducibly to reach a favorable efficacy and safety profile.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://www.sciencedirect.com/science/article/pii/B978032347720800002X
The data obtained show that utilization of this transporter as the tool for oral delivery is by mainly prodrug approaches (Kikuchi et al., 2008).Author: Rosa Martha Perez Gutierrez, Juan Vicente Mendez Mendez, Israel Arzate Vazquez
http://ijpsnonline.com/Issues/1057_full.pdf
Kinesh V.P. et.al. : Novel Approaches for Oral Delivery of Insulin and Current Status of Oral Insulin Products 1059 Approaches for oral Insulin Attempted Oral Insulin Delivery Systems Most peptides are not bioavailable from the GIT after oral administration (Cho YW et al., 1989).
https://www.sciencedirect.com/science/article/pii/S1359644606003084
To develop an oral delivery system with high bioavailability for biologicals it will be necessary to consider (1) modification of a physicochemical property (lipophilicity and enzyme susceptibility) of the macromolecules; (2) the addition of novel functionality (e.g. receptor recognition or cell permeability) to macromolecules; or (3) the use of a delivery carrier system.Author: Mariko Morishita, Nicholas A. Peppas
https://www.sciencedirect.com/science/article/pii/S1319016414000590
A novel absorption enhancer, viz. Zonula occludens toxin (ZOT) (Salama et al., 2006), chitosan (Prego et al., 2005), thiolated polymers (Bernkop-Schnurch, 2005) and Pz-peptide have all been studied as penetration enhancers for oral insulin delivery, and have resulted in effective reduction of glucose levels in the body (Fasano and Uzzau, 1997).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
Following approaches have been used as potential means to enhance the oral delivery of peptide-based pharmaceuticals. Molecular weight and size: Molecular weight and size influence the diffusion of drugs through the epithelial layer, the very large molecule have lower diffusivities and only small molecules (<75-100 Dalton) appear to cross the ...
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