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https://www.nature.com/articles/nmat1392
May 15, 2005 · The increase in endocytosis of the pDNA condensates and their import into the nucleus with the rise in stiffness of the adhesion substrate correlated with increased cell proliferation and survival ( Fig. 4 ). Gene transfer has also been previously noted to be enhanced by cell division …Author: Hyun Joon Kong, Jodi Liu, Kathryn Riddle, Takuya Matsumoto, Kent Leach, David J. Mooney
https://ui.adsabs.harvard.edu/abs/2005NatMa...4..460K/abstract
However, non-viral vectors are plagued by low levels of gene transfection and cellular expression. Current efforts to improve the efficiency of non-viral gene delivery are focused on manipulations of the delivery vector, whereas the influence of the cellular environment in DNA uptake is often ignored.Author: Hyun Joon Kong, Jodi Liu, Kathryn Riddle, Takuya Matsumoto, Kent Leach, David J. Mooney
https://mooneylab.seas.harvard.edu/publications/non-viral-gene-delivery-regulated-stiffness-cell-adhesion-substrates
However, non-viral vectors are plagued by low levels of gene transfection and cellular expression. Current efforts to improve the efficiency of non-viral gene delivery are focused on manipulations of the delivery vector, whereas the influence of the cellular environment in DNA uptake is often ignored.
https://www.researchgate.net/publication/292726692_Non-viral_gene_delivery_regulated_by_stiffness_of_cell_adhesion_substrates
Non-viral gene delivery is evolving, but is further complicated by the cell of choice, human BMSCs, which are notoriously difficult to transfect.
https://www.researchgate.net/publication/7846513_Kong_HJ_Liu_J_Riddle_K_Matsumoto_T_Leach_K_and_Mooney_DJ_Non-viral_gene_delivery_regulated_by_stiffness_of_cell_adhesion_substrates_Nat_Mater_4_460-464
Non-viral gene vectors are commonly used for gene therapy owing to safety concerns with viral vectors. However, non-viral vectors are plagued by low levels of gene transfection and cellular ...
https://www.sciencedirect.com/science/article/pii/S1742706112001614
In this study, we hypothesized that the stiffness of a cell adhesion matrix regulates non-viral gene delivery to various extents for different cell types due to changes in gene uptake and intracellular processes affecting gene expression.Author: Cathy Chu, Hyunjoon Kong
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