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https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The concentration of drug, dose, and volume of dose administered are all important factors that can affect nasal drug delivery to the brain. Nasal drug absorption increases as the concentration of drug increases at the site of administration. This phenomenon is more prominent with drugs that are absorbed by passive diffusion as a primary ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nanoemulsions for nasal administration represent a promising strategy for nose-to-brain drug delivery and to achieve CNS targeting for the treatment of neurodiseases. However, clinical studies of these formulations are still needed to demonstrate their appropriateness in clinical practice.Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.ncbi.nlm.nih.gov/pubmed/29277310
Feb 15, 2018 · Mechanism of intranasal drug delivery directly to the brain. Crowe TP(1), Greenlee MHW(1), Kanthasamy AG(1), Hsu WH(2). ... The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves. The purpose of this review is to describe the details of this mechanism to better direct ...Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.slideshare.net/ishanipandit034/brain-targeted-drug-delivery-through-nasal-route
Mar 01, 2015 · Brain Targeted Drug Delivery through Nasal Route ... RATIONALE OF NOSE TO BRAIN DELIVERY Currently, Nasal drug delivery has been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. Nasal administration is a logical choice for topical nasal treatments such as antihistamines and corticosteroids ...
https://www.sciencedirect.com/science/article/pii/S0168365917308258
Nasal drug delivery to brain. Nasal route has been explored for decades for systemic delivery of drugs which can't be given via oral route but now it has gained attraction and potential for direct IN delivery of neurotherapeutics to brain by circumventing the blood circulation, thus reducing the systemic exposure and hepatic/renal clearance , .Author: Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zhai
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
https://www.sciencedirect.com/science/article/pii/S0361923018303678
For nasal drug delivery, it is essential to investigate some factors that may affect the extent and the rate of drug absorption. These factors are metabolic stability, permeation mechanisms, and formulation of the drug. The well-known ex vivo nasal perfusion model for drug permeability is the Ussing chamber. The use of this model is simple so ...Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
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