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https://www.sciencedirect.com/science/article/pii/0167779994901236
The development of recombinant proteins, monoclonal antibodies, or antisense oligonucleotides as pharmaceuticals for the brain will require the parallel development of practical strategies for delivery of these pharmaceuticals in vivo through the endothelial wall of capillaries in the brain, the blood-brain barrier. The brain and spinal cord constitute the only organ to be perfused by ...Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
Modern methods of transporting drugs across the blood–brain barrier As previously stated, the various transport mechanisms across the BBB can be summarised as per Fig. 2 . The paracellular pathway, transcellular pathway, transport proteins, efflux pumps, RMT and adsorptive transcytosis described in Fig. 2 have long been accepted as potential transport routes for drug entering the brain [20] .Author: Yan Chen, Lihong Liu
https://health.economictimes.indiatimes.com/news/diagnostics/new-virus-inspired-method-to-deliver-drugs-to-brain-developed-study/71552372
Oct 12, 2019 · The study, published in the journal Nature Communications, noted that the new method allowed for combination drug delivery through an intravenous injection to cross the blood-brain-barrier …
https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue… Research on the delivery of therapeutics to the brain could have implications for the treatment of a wide range of diseases, such as Alzheimer’s, ALS, brain cancer and Parkinson’s.
https://www.news18.com/news/lifestyle/a-virus-inspired-method-for-drug-delivery-to-the-brain-developed-says-study-2343131.html
Oct 12, 2019 · The study, published in the journal Nature Communications, noted that the new method allowed for combination drug delivery through an intravenous injection to cross the blood-brain-barrier (BBB). The researchers, including those from Newcastle University in the UK, synthesized and modified components from a virus that targets the brain -- a bacteriophage fd -- to deliver drugs across the …
https://stories.abbvie.com/stories/how-to-overcome-blood-brain-barrier-to-deliver-new-medicines.htm
Jul 18, 2016 · The blood-brain barrier (BBB) is a complex and intricate system of cells that come together around the blood vessels in the brain. It maintains proper function of the brain, but it also makes it harder to discover and develop new medicines to treat diseases of the brain, such as Alzheimer’s disease, Parkinson’s and others.
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