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https://www.nature.com/articles/s41541-020-0172-y
Mar 24, 2020 · Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice Skip to main content Thank you for visiting nature.com.Author: Hiroki Takeuchi
https://www.mdpi.com/journal/pharmaceutics/special_issues/nose_brain_delivery
In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects.
http://jpet.aspetjournals.org/content/jpet/early/2019/05/24/jpet.119.258152.full.pdf
delivery to the brain via established quantification techniques. We have also highlighted clinical studies, where nose to brain delivery was the intended outcome. Nose to brain mechanism of delivery For the purposes of drug delivery, the nasal cavity is divided into the respiratory area
http://www.thepharmajournal.com/vol2Issue1/Issue_march_2013/14.pdf
olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.
https://www.optinose.com/exhalation-delivery-systems/nasal-delivery-challenges
Nasal Delivery Challenges Despite easy access, the complex and dynamic geometry of the nose makes reliable and efficient delivery of drugs to mucosal surfaces high and deep in the nose challenging. The nasal valve is the narrowest segment of the respiratory tract, accounting for up to 80% of nasal resistance and almost half of total respiratory ...
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
The Neuroanatomy of Intranasal Delivery. The cribriform plate of the skull separates the upper part of the nasal cavity from the brain. The primary olfactory nerves are located in the roof of the nasal cavity under the cribriform plate and include the olfactory sensory neurons and odorant receptors.
https://www.omicsonline.org/open-access/nose-to-brain-drug-delivery-a-recent-update.pdf
Nose to Brain Drug Delivery: A Recent Update
https://www.sciencedirect.com/science/article/pii/S0378517319303862
Different types of formulations and delivery systems are studied for the nose to brain drug delivery. Readers can go through available scientific compilation of different intranasal drug delivery systems (Warnken et al., 2016).The systems not only deliver small synthetic drugs, but also large molecules, such as protein or peptides, hormones, and stem cells, to obtain a therapeutic benefit.
https://www.mdpi.com/1999-4923/10/3/116/pdf
brain. Alternative drug delivery routes like intraparenchymal or intrathecal are invasive methods with a remaining risk of infections. In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain.
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S5
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic ...
https://www.slideshare.net/ishanipandit034/brain-targeted-drug-delivery-through-nasal-route
Mar 01, 2015 · Brain Targeted Drug Delivery through Nasal Route. ... INTRODUCTION Drug delivery through nasal route has been potentially explored as an alternative route for the administration of vaccines and biomolecules such as proteins, peptides and non-peptide drugs that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism ...
https://www.nature.com/articles/nb.1866
Intranasal delivery to the brain. To date, the majority of studies investigating this delivery mechanism have looked only at animal models 11, but both short- and long-term effects in humans have ...
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
intranasal delivery. Furthermore, for direct “nose-to-brain delivery”, by-passing the blood-brain barrier, the olfactory region enables drugs to enter the cerebrospinal space, for effective treatment of the central nervous system. “As aging-population demographics and managed-care initiatives drive growth in home health care and self ...
https://www.sciencedaily.com/releases/2013/04/130424185207.htm
Apr 24, 2013 · Nasal lining used to breach blood/brain barrier Date: April 24, 2013 Source: Massachusetts Eye and Ear Infirmary Summary: Using mucosa, or the lining of the nose, researchers have demonstrated ...
https://www.futurity.org/nasal-spray-brain-cancer-1859772/
While nasal brain drug delivery is a huge step forward, it isn’t yet possible to target a drug to a specific area. Chen’s targeted ultrasound technique is addressing that problem.
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