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https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
Mucodel Pharma enables drug delivery of rescue therapeutics across mucosal tissues using pH-optimized, transient supersaturation. Mucodel’s Co-Gel technology represents inspired leveraging of ‘highly unstable formulations’ of drug molecules to greatly improve their flux through mucosal barriers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
In recent years, many such mucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effects. Dosage forms designed for mucoadhesive drug delivery should be small and flexible enough to be acceptable for patients and should not cause irritation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
Nasal Mucoadhesive Drug Delivery Systems. The area of the normal human nasal mucosa is approximately 150 cm 2, a highly dense vascular network and relatively permeable membrane structure; all these factors make nasal cavity interesting. Drawbacks are local toxicity/irritation mucociliary clearance of 5 min, presence of proteolytic enzymes, and ...
https://www.future-science.com/doi/full/10.4155/tde.12.60
Jul 30, 2012 · The scope of the conference (Nasal and Buccal Drug Delivery Conference, Management Forum; Chairs Franz Merkus and Julie Suman) was to consider innovations in drug delivery via the nose and oral cavity, notably for the delivery of vaccines, antimalarials and rapidly acting sedatives.Author: John D Smart
https://www.ondrugdelivery.com/deposition-in-three-nasal-cast-models-using-expiratory-concept/
Citation: Vecellio L, Le Pennec D, Grevin G, Regard A, “Deposition in Three Nasal Cast Models Using RetroNose Concept”. ONdrugDelivery Magazine, Issue 96 (Apr 2019), pp 42-44. Laurent Vecellio, Déborah Le Pennec, Guillaume Grevin and Alain Regard discuss a study conducted to test particle deposition characteristics of the RetroNose device prototype for nasal drug delivery.
https://quizlet.com/79826361/nasal-sublingual-buccal-drug-delivery-flash-cards/
Nasal, Sublingual, Buccal Drug Delivery. STUDY. PLAY. Function of the nasal cavity. Filter, warm, and humidify the inhaled air and trap inhaled particles by the hairs or by the mucous layer. Nasal cavity consists of 3 regions: 1. Vestibule 2. Olfactory 3. Respiratory: mucociliary clearance mechanism is excellent for drugs to be absorbed.
https://www.slideshare.net/shivadheeraj/buccal-drug-delivery-system-14721771
Oct 14, 2012 · BUCCAL DRUG DELIVERY AND MUCOADHESIVITYMucoadhesion of the device is a key elementThe term ‘mucoadhesive’ is commonly used for materials that bind to the mucin layer of a biological membraneAchieve systemic delivery of drugs include tablets, patches, tapes, films, semisolids and powders 10. BIOADHESIVE DDSFOR MUCOSAL DRUG DELIVERY 11.
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