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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · This siRNA-based revolutionary approach can soon come to the market, depending on the results of several active Phase III clinical trials.5,6 This review will focus on siRNA delivery by lipid nanoparticles (LNPs) and the current status of clinical trials for these systems. In the first section, we will describe the different components forming ...Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.sciencedirect.com/science/article/pii/S0378517317302880
Polymeric nanoparticles for siRNA delivery: Production and applications ... with the advancement of siRNA delivery, it will be possible to advance siRNA therapeutics rapidly into clinical studies, but there are still many factors to be refined and tuned also in the research approaches: evaluation of the efficacy of siRNA therapeutics is ...Author: Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio, Gaetano Giammona
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836621/
Sep 18, 2013 · Lipid nanoparticle (LNP) containing ionizable amino lipids is the leading delivery technology for siRNA, with five products in clinical trials and more in the pipeline. Here, we focus on the technological advances behind these potent systems for siRNA-mediated gene silencing.Author: Yuen Yi C. Tam, Sam Chen, Pieter R. Cullis
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · Lipidoid synthesis and nanoparticle formulation. In order to develop efficacious, degradable nanoparticles for siRNA delivery while conducting …Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.mdpi.com/2227-9059/8/4/76/htm
Selenium nanoparticles (SeNPs) have the potential to increase delivery efficiency, to reduce side effects, and to improve therapeutic outcomes. In this study, chitosan (Ch) functionalized folate (FA)-targeted SeNPs were synthesized, characterized, and evaluated for their potential to bind, protect, and safely deliver Fluc-siRNA in vitro.
https://www.nature.com/articles/nnano.2012.73
Nanoparticles with a diameter greater than 20 nm avoid renal clearance, which is a typical outcome for monomeric siRNA, and enhance delivery to certain tumour types through the enhanced ...Author: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
https://pubag.nal.usda.gov/catalog/6783673
alkylation, biocompatibility, cell lines, curdlan, cytotoxicity, genes, melanoma, mice, nanoparticles, phenotypic plasticity, polymers, small interfering RNA, therapeutics, transfection Abstract: Cationic curdlan derivatives are a class of promising carriers for nucleic acid delivery including short interfering RNA (siRNA).
https://en.wikipedia.org/wiki/Small_interfering_RNA
One of the biggest challenges to siRNA and RNAi based therapeutics is intracellular delivery. Delivery of siRNA via nanoparticles has shown promise. siRNA oligos in vivo are vulnerable to degradation by plasma and tissue nucleases and have shown only mild effectiveness in localized delivery …
https://advances.sciencemag.org/content/6/13/eaaz6108.full
Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo. Here, we report on a platelet cell membrane–coated metal-organic framework (MOF) nanodelivery platform for the targeted delivery of siRNA in vivo.
https://www.sciencedirect.com/science/article/pii/S0021979712010570
Over recent years, clay-based nanoparticles, layered double hydroxides (LDHs), have emerged as a siRNA delivery system with the potential to fulfill the above criteria.Author: Min Chen, Helen M. Cooper, Ji Zhi Zhou, Perry F. Bartlett, Zhi Ping Xu
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