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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523670/
Apr 02, 2019 · Zhu et al. also developed aldehyde-functionalized dendritic mesoporous silica nanoparticles (DMSNs-CHO) with an average particle size of 174 nm and an internal pore size of 7.7 nm as a potential pH-responsive protein drug delivery system . They loaded BSA as a model protein into the pores of DMSNs-CHO and found its release was dependent on environment pH.Author: Hai-Jun Liu, Peisheng Xu
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic. KEY WORDS: protein and peptide drugs; nanoparticles; oral delivery; bioavailability. INTRODUCTION Since the first bioactive peptide was synthesized in 1953 by Robert Bruce Merrifield, the research of protein andAuthor: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.sciencedirect.com/science/article/pii/S0168365915301802
In protein delivery, nanoparticle technologies can: i) protect proteins from premature degradation or denaturation in biological environment; ii) enhance systemic circulation half-life of proteins with poor pharmacokinetic properties; iii) control sustained and/or tunable release which can maintain drug concentration in the therapeutic range; and iv) target diseased tissues, cells, and intracellular …Author: Mikyung Yu, Jun Wu, Jinjun Shi, Omid C. Farokhzad, Omid C. Farokhzad
http://ijpsr.com/bft-article/protein-nanoparticles-future-of-drug-delivery-systems/?view=fulltext
Parenteral delivery of Protein 19: Now a day self-administered injectables are available that are in expensive and easy to deliver protein drug. Antibiotics with Protein nanoparticles: Antibiotics are other drugs that were shown to yield an increase in efficacy or a decrease in toxicity after ...
https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00244k
Tremendous efforts have been devoted to developing efficient protein delivery systems. The past decade has witnessed the development and successful application of silica-based nanoparticles (SiNPs) as therapeutic protein carriers. This review focuses on recent advances in SiNPs in therapeutic protein delivery for disease and cancer treatment.Author: Meihua Yu, Zhengying Gu, Thomas Ottewell, Thomas Ottewell, Chengzhong Yu
https://www.nature.com/articles/s41551-019-0465-5
Here we show that anionic nanoparticles induce tight junction relaxation, increasing intestinal permeability and enabling the oral delivery of proteins. This permeation-enhancing effect is a...Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
https://www.mdpi.com/2079-4991/8/11/886/pdf
concerning protein encapsulation, protection during intracellular trafficking and final release triggered by nanoparticle degradations in acidic organelles. We believe this proof of principle may open new applications and developments for targeted and efficient protein delivery.Author: Filippo Begarani, Domenico Cassano, Eleonora Margheritis, Roberto Marotta, Francesco Cardarelli, Val...
https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b01098
In addition, protein-based nanoparticles offer the opportunity for surface modification by conjugation of other protein and carbohydrate ligands. This enables targeted delivery to the desired tissue and organ, which further reduces systemic toxicity.Author: Annish Jain, Sumit K. Singh, Shailendra K. Arya, Subhas C. Kundu, Sonia Kapoor, Sonia Kapoor
https://www.nature.com/articles/s41467-018-06979-4
Oct 31, 2018 · Fig. 1. Protein corona shield nanoparticle (PCSN). a We introduce the protein corona shield (PCS) concept for an efficient target drug delivery system. Generally, nanoparticle drug carriers with a target ligand lose their targeting ability on being coated by blood proteins in a …Author: Jun Yong Oh, Han Sol Kim, L. Palanikumar, Eun Min Go, Batakrishna Jana, Soo Ah Park, Ho Young Kim, K...
https://www.hindawi.com/journals/bmri/2014/180549/
Protein nanoparticles have been most extensively used for the delivery of anticancer drugs. Cancer is a major cause of death with no effective treatments. Approximately 12.7 million people were diagnosed with cancer worldwide in 2008 and this number is expected to increase to 21 million by 2030 [76].Author: Warangkana Lohcharoenkal, Liying Wang, Yi Charlie Chen, Yon Rojanasakul
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