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https://www.sciencedirect.com/science/article/pii/S0142961219302376
Bioreducible polymeric nanoparticles encapsulating siRNA combinations are successfully delivered to human glioblastoma cells in vitro and in vivo.Author: Kristen L. Kozielski, Kristen L. Kozielski, Alejandro Ruiz-Valls, Stephany Y. Tzeng, Hugo Guerrero-C...
https://pubs.acs.org/doi/10.1021/nn301922x
A significant challenge in the development of clinically viable siRNA delivery systems is a lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell culture do not retain efficacy in animals. Despite its importance, little information exists on the predictive nature of in vitro methodologies, most likely due to the cost and time associated with ...
https://www.precisionnanosystems.com/resource-center/publications/detail/lipid-nanoparticle-mediated-sirna-delivery-for-safe-targeting-of-human-cml-in-vivo
May 18, 2019 · Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of siRNA to the liver; however, delivery to other organs, especially hematopoietic tissues still remains a challenge.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0365-y
Here, porous silicon nanoparticles (pSiNPs) that enable high-capacity loading and delivery of siRNA are applied in vitro and in vivo. We established pSiNPs with polyethyleneimine (PEI) capping that enables high-capacity loading of siRNA (92 µg of siRNA/mg PEI-pSiNPs), and optimised release profile (70% released between 24 and 48 h).
https://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra25862j
Previously, we reported peptidomimetic based lipid nanoparticles for successful siRNA delivery in vivo. 28 DoGo3 lipids showed enhanced biocompatibility while exhibiting high potential for liver targeted siRNA delivery at higher doses. In this study, in order to increase the siRNA delivery efficacy of DoGo lipids,...
https://www.pnas.org/content/115/42/E9944
Oct 16, 2018 · We quantified how >250 lipid nanoparticles (LNPs) delivered mRNA in vivo, identifying two LNPs that deliver mRNA to endothelial cells. One of the LNPs codelivered Cas9 mRNA and single-guide RNA in vivo, leading to endothelial cell gene editing. This approach can …
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201902251
Aug 29, 2019 · Given that T cells endocytose lipoprotein particles and enveloped viruses, two natural systems with structures that can be similar to lipid nanoparticles (LNPs), it is hypothesized that LNPs devoid of targeting ligands can deliver RNA to T cells in vivo. To test this hypothesis, the delivery of siRNA to 9 cell types in vivo by 168 nanoparticles using a novel siGFP‐based barcoding system and …
https://www.nature.com/articles/s41565-020-0669-6?error=cookies_not_supported&code=77395623-c20b-4a56-a39c-72d2c8d16cc2
Sago, C. D. et al. High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
https://ieeexplore.ieee.org/document/7784799/
Dec 15, 2016 · Small interfering RNA (siRNA) is an important RNAi tool that has found significant application in cancer therapy. However due to lack of stability, poor cellular uptake and high probability of loss-of-function due to degradation, siRNA therapeutic strategies seek safe and efficient delivery vehicles for in vivo applications.
https://www.hindawi.com/journals/bmri/2013/782041/
Chemically modified and folate receptor-targeted packaging RNA nanoparticles for siRNA delivery showed high in vivo stability with a blood half-life of 5 to 10 …
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201203263
Jul 10, 2012 · Special (lipid) delivery: The role of the ionizable lipid pK a in the in vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group modifications to the lipids. A tight correlation between the lipid pK a value and silencing of the mouse FVII gene (FVII ED 50) was found, with an optimal pK a range of 6.2–6.5 (see graph).
https://www.dahlmanlab.org/uploads/5/8/5/6/58561089/lokugamage_et_al-2019-advanced_materials.pdf
systems with structures that can be similar to lipid nanoparticles (LNPs), it is hypothesized that LNPs devoid of targeting ligands can deliver RNA to T cells in vivo. To test this hypothesis, the delivery of siRNA to 9 cell types in
https://www.sciencedirect.com/science/article/pii/S1525001620300538
Apr 08, 2020 · However, development of these delivery systems remains the main challenge today. 4 Among several systems for siRNA delivery in vivo, lipid nanoparticles (LNPs) are robust, efficient, and clinically validated and provide efficient delivery to the liver. 5, 6 During circulation in the bloodstream, LNPs are covered by a protein corona, including ...
https://www.researchgate.net/profile/Kathryn_Whitehead/publication/263516008_Degradable_Lipid_Nanoparticles_with_Predictable_In_Vivo_siRNA_Delivery_Activity/links/5449b8410cf244fe9ea60e5e.pdf
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity Kathryn A. Whitehead1,w, ... predict in vivo siRNA delivery efficacy without any prior biological testing.
http://www.thno.org/v07p1990.htm
Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo. Xi Zhu 1, 2*, Wei Tao 1*, Danny Liu 1, 3, Jun Wu 1, 4, Zilei Guo 1, Xiaoyuan Ji 1, Zameer Bharwani 1, Lili Zhao 1, 5, Xiaoping Zhao 2, Omid C. Farokhzad 1, 6 , Jinjun Shi 1 . 1.
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