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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · 4. Proteins and Peptide Nanomaterials for Gene Delivery. Proteins are attractive as gene delivery vectors, because of their biocompatibility, biodegradability and, typically, minimal toxicity . Their amphiphilic nature allows them to interact with both the solvent and the specific cargo (DNA, RNA or therapeutic agent) of choice.Author: Michael K. Riley, Wilfred Vermerris
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
An ability to control nanoparticle stability, DNA or RNA release, cell binding, and intracellular trafficking will be the key to understanding the rate-limiting steps for gene delivery and to optimizing transgene expression efficiency in vivo.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Ionizable lipids are an advanced delivery platform of gene therapy that can self-assemble into nanoparticles when mixed with polyanionic nucleic acids. Ionizable cationic lipids with modulated pKa values increase nucleic acid payload and enhance the therapeutic efficacy of gene therapy.Author: Yi Zhao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/
Apr 06, 2016 · CALLA-01, a targeted nanoparticle system based on cyclodextrins, has been developed for the first in-human phase-1 clinical trial. 8,29 Chitosan is another typical naturally polycation with the advantages of biocompatibility and biodegradability, which will be served as a very promising carrier for gene delivery. 30 Lipid-based nanoparticles are one of the most extensively explored for gene delivery …Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
http://onlinelibrary.wiley.com/doi/10.1002/smll.201202485/full
Nanocarriers are a new type of nonviral gene carriers, many of which have demonstrated a broad range of pharmacological and biological properties, such as being biodegradable in the body, stimulus‐responsive towards the surrounding environment, and an abiltiy to specifically targeting certain disease …
https://www.researchgate.net/publication/7141587_Nanoparticles_for_Gene_Delivery
Liposomes conjugated polymer/metal nanoparticles, and hybrid Quantum Dots (QD) core derived gene delivery vehicle were also studied for improved tranfection efficiency in prescribed and controlled...
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Production and clinical development of nanoparticles for gene delivery. Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.sciencedirect.com/science/article/pii/B9780081005576000043
From these studies, it has been postulated that bioreducible cross-linked polymeric nanoparticles have been shown as efficient and safe gene delivery vehicles because of their stability in an extracellular medium and rapid degradation in a reductive intracellular environment which facilitates release of the bound DNA for nuclear localization.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
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