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http://www.nature.com/articles/3301874
Jan 14, 2003 · Transgenes can be delivered to muscle using viral or non-viral systems. Although the pioneer study used naked plasmid DNA for gene delivery, 1 the low efficiency of …
https://www.ncbi.nlm.nih.gov/pubmed/12571642
1. Gene Ther. 2003 Jan;10(2):131-42. Non-viral gene delivery in skeletal muscle: a protein factory. Lu QL(1), Bou-Gharios G, Partridge TA. Author information: (1)Muscle Cell Biology Group, MRC Clinical Sciences Center, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London W12 0NN, UK.Author: Ql L. Lu, George Bou-Gharios, Ta A. Partridge
https://www.researchgate.net/publication/10913186_Non-viral_gene_delivery_in_skeletal_muscle_A_protein_factory
Non-viral gene delivery in skeletal muscle: A protein factory Article · Literature Review (PDF Available) in Gene Therapy 10(2):131-42 · February 2003 with 102 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.sciencedirect.com/science/article/pii/S0006291X12011850
Jul 27, 2012 · Gene transfer to skeletal muscle by site-specific delivery of electroporation and ultrasound. ... These results demonstrate that site-specific DNA delivery to muscle can give rise to therapeutic protein for CNS therapy, ... Q.L. Lu, G. Bou-Gharios, T.A. PartridgeNon-viral gene delivery in …Author: Yuanli Li, Junqing Wang, Andrew Satterle, Qunqiang Wu, Jue Wang, Feng Liu
https://link.springer.com/chapter/10.1007/978-3-030-03095-7_9
Mar 31, 2019 · Abstract. Non-viral gene delivery to skeletal muscle was one of the first applications of gene therapy that went into the clinic, mainly because skeletal muscle is an easily accessible tissue for local gene transfer and non-viral vectors have a relatively safe and low immunogenic track record.Author: Serge Braun
https://core.ac.uk/display/77482731
Non-viral gene delivery in skeletal muscle: a protein factory. By QL Lu, ... there are potential benefits in the use of non-viral vectors. In this review we assess the recent advances in construction and delivery of naked plasmid DNA to skeletal muscle and highlight the options available for further improvements to raise efficiency to ...Author: QL Lu, G Bou-Gharios and TA Partridge
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(04)00170-4
High levels of transgene expression in skeletal muscle were achieved in both small and large animals with minimal toxicity. Evidence of siRNA delivery to limb muscle was also obtained. The simplicity, effectiveness, and safety of the procedure make this methodology well suited to limb muscle gene therapy applications.Author: James E. Hagstrom, Julia Hegge, Guofeng Zhang, Mark Noble, Vladimir Budker, David L. Lewis, Hans Her...
https://www.researchgate.net/publication/270394767_Non_Viral_Vectors_in_Gene_Therapy-_An_Overview
Non Viral Vectors in Gene Therapy- An Overview. ... FDA as vehicle for protein delivery. ... Gharious GB, Partridge TA. Non viral gene delivery in skeletal muscle : a . protein factory.Author: Murali Ramamoorthi
https://www.nature.com/articles/nrneurol.2017.126
Sep 29, 2017 · Genome engineering tools, including targeted gene editing and gene regulation, are becoming available to correct the mutations that cause neuromuscular disorders such as muscular dystrophy, spinal ...Author: Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Charles A. Gersbach, Charles A. Gersbach
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