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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems INTRODUCTION Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[ 1 ]
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
http://www.eurekaselect.com/106191/article
In order to improve gene transfer efficacy, a lot of efforts have been made in the past years, and numerous gene carriers and techniques have been developed. In this review, we summarized the features, drawbacks and prospects of existing and emerging non-viral gene delivery methods.
https://onlinelibrary.wiley.com/doi/full/10.1002/jgm.3092
Apr 16, 2019 · Non‐viral gene delivery systems show a lower transfection efficacy and transient gene expression compared to viral vectors; however, non‐viral vectors are of much lower immunogenicity than the viral vectors. Recent studies have demonstrated that the transfection efficiency of the non‐viral carriers can also be dramatically improved by ...Author: Weiqi Wang, Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu
Learn how BMoGen is utilizing their unique expertise to provide gene editing services including fee-for-service and non-viral transposon based gene delivery platforms that address complex gene delivery and gene editing enabling scientists and bio-therapeutics companies to create life …
http://juventasinc.com/non-viral-gene-therapy.html
Localized drug delivery. A non-viral DNA plasmid is delivered directly to the site of injured tissue creating a localized homing signal at the site of delivery, with no significant expression of the therapeutic protein observed outside the targeted organ.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The non-viral vectors are Naked DNA, particle based and chemical based. They are administered by direct administration (plasmid DNA/Naked DNA)/ chemical /physical. Most of cardiovascular clinical trials use non-viral vectors as a mode of gene transfer.Author: Murali Ramamoorth, Aparna Narvekar
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Non-viral gene delivery methods like electroporation and chemical transfection reagents are an attractive alternative due to their reduced cost, their easy adaptation to various cargo, and their improved safety profile compared to viral vectors but historically have low gene transfer efficiencies in T cells [ …Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
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