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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096447/
Dec 03, 2007 · Other in vivo delivery approaches for siRNAs include aptamer-siRNA conjugates that specifically inhibit tumor growth and mediate tumor regression in a xenograft model of prostate cancer (93) and the use of a chitosan-based siRNA nanoparticle delivery system to knockdown EGFP both in vivo and in vitro (94).Author: Saghir Akhtar, Ibrahim F. Benter
https://www.jci.org/articles/view/33494
Other in vivo delivery approaches for siRNAs include aptamer-siRNA conjugates that specifically inhibit tumor growth and mediate tumor regression in a xenograft model of prostate cancer ( 93) and the use of a chitosan-based siRNA nanoparticle delivery system to …
https://www.ncbi.nlm.nih.gov/pubmed/18060020
Nonviral delivery of synthetic siRNAs in vivo. Akhtar S(1), Benter IF. Author information: (1)SA Pharma, Sutton Coldfield, West Midlands, United Kingdom. Sequence-specific gene silencing using small interfering RNA (siRNA) is a Nobel prize-winning technology that is now being evaluated in clinical trials as a potentially novel therapeutic strategy.Author: Saghir Akhtar, Ibrahim F. Benter
https://www.jci.org/articles/view/33494/figure/1
Nonviral delivery of synthetic siRNAs in vivo. ... This article provides an overview of the major pharmaceutical challenges facing siRNA therapeutics, focusing on the delivery strategies for synthetic siRNA duplexes in vivo, as this remains one of the most important issues to be resolved. This article also highlights the importance of ...Author: Saghir Akhtar, Ibrahim F. Benter
https://dm5migu4zj3pb.cloudfront.net/manuscripts/33000/33494/JCI0733494.v1.pdf
in vivo. The challenges for effective siRNA delivery and activity in vivo range from the effective empirical or in silico design and selection of an effective siRNA sequence to its chemical modification or formulation with delivery vectors to improve biological stability and pharmacoki-netics (steps i–iv).
https://www.semanticscholar.org/paper/Nonviral-delivery-of-synthetic-siRNAs-in-vivo.-Akhtar-Benter/0027911a04242f0b67f5fb56076e00124a104519
Sequence-specific gene silencing using small interfering RNA (siRNA) is a Nobel prize-winning technology that is now being evaluated in clinical trials as a potentially novel therapeutic strategy. This article provides an overview of the major pharmaceutical challenges facing siRNA therapeutics, focusing on the delivery strategies for synthetic siRNA duplexes in vivo, as this remains one of ...
https://europepmc.org/articles/PMC2096447
Dec 01, 2007 · Europe PMC is an archive of life sciences journal literature.Author: Saghir Akhtar, Ibrahim F. Benter
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Viral delivery systems have serious problems. Therefore, non-viral systems are more attractable than viral systems for siRNAs. Cationic lipids, liposomes, and polymers such as chitosan, PEI, PLL, and PLGA are used as non-viral siRNA delivery system. However, more suitable carriers are needed for siRNA delivery systems.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
https://www.researchgate.net/publication/11746751_Gene_delivery_with_synthetic_non_viral_carriers
Gene delivery with synthetic (non viral) carriers Article · Literature Review in International Journal of Pharmaceutics 229(1-2):1-21 · November 2001 with 37 Reads How we measure 'reads'
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201610209
Dec 16, 2016 · Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA. These authors contributed equally to this work. These authors contributed equally to this work. These authors contributed equally to this work.Author: Jason B. Miller, Shuyuan Zhang, Petra Kos, Hu Xiong, Kejin Zhou, Sofya S. Perelman, Hao Zhu, Daniel ...
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