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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
The success of gene therapy is highly dependent on the delivery vector. Viral vectors have dominated the clinical trials in gene therapy for its relatively high delivery efficiency. However, the improvement of efficacy of non-viral vectors has lead to an increased number of products entering into clinical trials.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
http://juventasinc.com/non-viral-gene-therapy.html
Gene therapy generally refers to the delivery of DNA into a patient’s cells to treat a target disease. The two major classes of gene therapy are viral, which uses recombinant viruses to promote long-term or permanent genomic modification, and non-viral, which uses a naked DNA plasmid to promote short-term therapeutic protein expression locally at the site of drug administration.
https://www.sciencedirect.com/topics/medicine-and-dentistry/non-viral-vector
Non-viral vectors. Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed. Furthermore, physical approaches including, for example, electroporation and gene ...
http://www.genetherapynet.com/non-viral-vectors.html
Non-viral methods present certain advantages over viral methods, with simple large scale production and low host immunogenicity being just two. Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technolog...
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