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http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1872-2113&volume=3&issue=2&spage=125
Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other gene delivery systems. This article reviews the advances of nanoparticles in patents for gene delivery and emphasizes methods to promote gene transfection efficiency.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · The use of nanoparticles in gene delivery can provide both the targeted and sustained gene delivery by protecting the gene against nuclease degradation and improving its stability [19-22]. Figure 1 Internalization of non-viral vectors into cell and …Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://patents.google.com/patent/WO2015042585A1/en
The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.Author: Shiva Prasad Kotha, Andre Ronald Watson, Vaibhav A. Pandit
https://www.semanticscholar.org/paper/Nanoparticles-in-Different-Delivery-Systems%3A-A-Nagal-Singla/05f0fba02cbc86f3432630fc5351f5592e5ab446
Nanoparticles are particulate dispersions or solid particles with a size in the range of 10-1000nm. The drug is dissolved, entrapped, encapsulated or attached to a nanoparticle matrix. Based upon the method of preparation, nanoparticles, nanospheres or nanocapsules can be obtained.
https://patents.justia.com/patent/9719108
Sep 22, 2015 · The unique properties of nanoparticles can be exploited for delivering DNA into cells. Among the nanoparticles investigated (e.g., tungsten, aluminum, nickel, etc.), Gold NanoParticles (GNP) tend to be excellent candidates for delivery of DNA.
https://www.sciencedirect.com/science/article/pii/B9780128140291000041
1. Introduction. Nanotechnology has provided an attractive niche for research in drug delivery. The prefix nano is derived from the Greek word dwarf.One nanometer (nm) is equal to one-billionth of a meter, that is, 10 −9 m .Due to increased surface area and quantum effects, nanomaterials differ from other conventional materials.Author: Vivek P. Chavda
https://www.researchgate.net/publication/7141587_Nanoparticles_for_Gene_Delivery
Nanoparticles for Gene Delivery. Since the evolution of the concept of gene therapy, delivering therapeutic genes to the diseased cells has been a major challenge. Although viral vectors have been shown to be efficient in delivering genes, the issue of their safety is still to be solved.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/
Apr 06, 2016 · Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.sciencedirect.com/science/article/pii/S0169409X02002284
2.4.1. Sustained gene delivery. Rapid escape of nanoparticles from the degradative endo-lysosomal compartment to the cytoplasmic compartment and their sustained intracellular retention suggest that nanoparticles containing encapsulated plasmid DNA could serve as an efficient sustained release gene delivery system . The therapeutic efficacy of the nanoparticles could be due to their ability to protect …Author: Jayanth Panyam, Vinod D Labhasetwar
https://www.researchgate.net/publication/305655393_Nanoparticles_in_Gene_Therapy
A major approach discussed is the use of Nanoparticles as non-viral carriers for gene delivery purposes regarding their favorable characteristics such as their nano-metric size, high surface to volume ratio, stability, their ability of undergoing surface modifications, their ability to encapsulate nucleic acids...
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