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https://www.researchgate.net/publication/5850101_Nanoparticles_for_drug_delivery_to_the_lungs
The lungs are an attractive route for non-invasive drug delivery with advantages for both systemic and local applications. Incorporating therapeutics with polymeric nanoparticles offers additional ...
https://www.nature.com/articles/nbt.1735
Little is known about the fate of nanoparticles that enter the lungs, ... including the design of nanoparticles for drug delivery and the evaluation of the toxicity of particulate air pollution.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Nanoparticles used in drug delivery system Biopolymeric nanoparticles. There are numerous biopolymeric materials that are utilized in the drug delivery systems. These materials and their properties are discussed below. Chitosan. Chitosan exhibits muco-adhesive properties and can be used to act in the tight epithelial junctions.
https://www.researchgate.net/publication/336452998_Nanoparticles_in_the_treatment_of_chronic_lung_diseases
nanoparticles for drug delivery pur poses and for vaccines . against tetanus, diphtheria, and other infections (2). ... for next-generation drug delivery to the lungs. Eur .
https://www.hindawi.com/journals/jnm/2013/863951/
The smaller dendrimer particles are reported to enter the blood stream via inhalation while larger particles are sequestered in the lung for an extended period of time. In the future, this method of controlled drug delivery to the lungs could provide an alternative to injectable drug systems.
https://phys.org/news/2017-04-nanoparticles-mucus-membranes-lungs-pulmonary.html
Apr 06, 2017 · Nanoparticles pass through mucus membranes in lungs to deliver pulmonary drugs ... by providing a therapy that maintains drug levels in the lungs for ... for pulmonary drug delivery …
https://www.intechopen.com/books/nanomedicines/silver-nanoparticles-as-multi-functional-drug-delivery-systems
Nanomedicine is a branch of medicine that uses nanomaterials and applies nanotechnologies in prevention, diagnostics, and treatment of diseases [].The broad definition of nanomedicine involves nanoparticles (NPs) as drug delivery systems (DDSs), medical nanosensor, biochips, insulin pumps, needleless injectors, etc.
https://www.nature.com/articles/s41598-017-13320-4
Oct 16, 2017 · Hence, particles with sizes less than 0.5 µm would be ideal for pulmonary drug delivery. PLGA-magnetic nanoparticles (293 nm size) developed by Verma et …
https://pubs.acs.org/doi/10.1021/nn404853z
Nanoparticulate drug delivery systems are one of the most widely investigated approaches for developing novel therapies for a variety of diseases. However, rapid clearance and poor targeting limit their clinical utility. Here, we describe an approach to harness the flexibility, circulation, and vascular mobility of red blood cells (RBCs) to simultaneously overcome these limitations (cellular ...
https://www.acs.org/content/acs/en/pressroom/presspacs/2017/acs-presspac-may-3-2017/nanoparticles-can-travel-from-lungs-to-blood-possibly-explaining-heart-risks.html
In the new study, 14 healthy volunteers, 12 surgical patients and several mouse models inhaled gold nanoparticles, which have been safely used in medical imaging and drug delivery. Soon after exposure, the nanoparticles were detected in blood and urine.
https://www.routledge.com/Nanoparticles-in-the-Lung-Environmental-Exposure-and-Drug-Delivery-1st/Tsuda-Gehr/p/book/9781439892794
Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding of how inhaled nanoparticles behave in the human lungs and body. Featuring contributions from renowned ...
https://link.springer.com/chapter/10.1007%2F978-3-030-06115-9_17
Mar 12, 2019 · This system could result in a sustained drug level in the plasma for 14 days and in the lung for 15 days. Similarly, PLGA nanoparticles which were formulated with sodium alginate and chitosan provided a sustained drug delivery to the lungs of guinea pigs in vivo to eradicate tubercle bacilli from M. tuberculosis-infected guinea pigs .
https://www.technologyreview.com/s/421689/what-happens-when-you-breathe-in-nanoparticles/
Nov 16, 2010 · What Happens When You Breathe In Nanoparticles. ... designing nanoparticles as drug-delivery vehicles, we need to start understanding what the rules are. ... approaches for not only local delivery ...
https://advances.sciencemag.org/content/3/4/e1601556.full
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that avoid mucoadhesion and have diameters smaller than mucus mesh spacings rapidly ...
https://arstechnica.com/science/2010/11/why-do-some-nanoparticles-get-trapped-in-our-lungs/
Nov 08, 2010 · Why do some nanoparticles get trapped in our lungs? ... nanoparticles through the lung for drug delivery and disease diagnostics. ... rat lungs to their pool of nanoparticles …
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