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https://www.pnas.org/content/108/6/2426
Feb 08, 2011 · Multistage nanoparticle delivery system for deep penetration into tumor tissue Cliff Wong , Triantafyllos Stylianopoulos , Jian Cui , John Martin , Vikash P. Chauhan , Wen Jiang , Zoran Popović , Rakesh K. Jain , Moungi G. Bawendi , and Dai FukumuraAuthor: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.ncbi.nlm.nih.gov/pubmed/21245339
Feb 08, 2011 · Multistage nanoparticle delivery system for deep penetration into tumor tissue. Wong C(1), Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D. Author information: (1)Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.pnas.org/content/pnas/108/6/2426.full.pdf
Multistage nanoparticle delivery system for deep penetration into tumor tissue Cliff Wonga, Triantafyllos Stylianopoulosb, Jian Cuia, John Martinb, Vikash P. Chauhanb, Wen Jiangb, Zoran Popovic´a, Rakesh K. Jainb, Moungi G. Bawendia,1, and Dai Fukumurab,1 aDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; and bEdwin L. Steele Laboratory for Tumor Biology ...Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038705/
Feb 08, 2011 · Multistage nanoparticle systems provide additional tunability in the spatial control of delivery to solid tumors. Because of the multiple physiological barriers that a therapeutic agent must encounter, a multistage nanoparticle system can enhance penetration by changing its size, charge, shape, flexibility, and/or surface coating to suit the ...Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201807294
Overcoming Hypoxia by Multistage Nanoparticle Delivery System to Inhibit Mitochondrial Respiration for Photodynamic Therapy. ... are encapsulated in a gelatin nanoparticle, whose structure would rupture to promote deep penetration when facing matrix metallopeptidase 2 enzyme overexpression in tumor tissue. The antihypoxic performance of the ...Author: Donglin Xia, Donglin Xia, Peipei Xu, Xingyu Luo, Jianfeng Zhu, Haiying Gu, Da Huo, Yong Hu
http://dspace.mit.edu/handle/1721.1/65152
Multistage nanoparticle delivery system for deep penetration into tumor ... DownloadWong-2011-Feb-Multistage nanoparticle delivery system.pdf (1.129Mb ... In vivo circulation half-life and intratumoral diffusion measurements indicate that our multistage nanoparticles exhibited both the long circulation half-life necessary for the EPR effect and ...
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