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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327631/
Jan 07, 2017 · Multistage drug delivery systems (Ms-DDS), also referred to as stimuli-responsive or activatable systems, show different behaviors during systemic circulation and in the tumor microenvironment. Ms-DDS have been developed in the 1970s when the first thermo-sensitive liposome for accelerated and quick release of drugs in the tumor was designed 8 .Author: Binlong Chen, Wenbing Dai, Bing He, Hua Zhang, Xueqing Wang, Yiguang Wang, Qiang Zhang
https://www.ncbi.nlm.nih.gov/pubmed/28255348
Jan 07, 2017 · The development of traditional tumor-targeted drug delivery systems based on EPR effect and receptor-mediated endocytosis is very challenging probably because of the biological complexity of tumors as well as the limitations in the design of the functional nano-sized delivery systems. Recently, multistage drug delivery systems (Ms-DDS) triggered by various specific tumor microenvironment …Author: Binlong Chen, Wenbing Dai, Bing He, Hua Zhang, Xueqing Wang, Yiguang Wang, Qiang Zhang
https://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra18833d
A multistage drug delivery system was designed, which showed MMP-2 sensitive shrinkage and enhanced penetration properties.Author: Guanlian Hu, Yang Wang, Qin He, Huile Gao, Huile Gao
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201303662
Abstract. Efficient delivery of DNA‐toxin anticancer drugs into nucleus of targeted tumor cells while simultaneously minimizing the side effects to normal tissue is a major challenge for cancer therapy. Herein, a multistage continuous targeting strategy based on magnetic mesoporous silica nanoparticles to overcome the challenge is demonstrated.Author: Zhenhua Li, Kai Dong, Sa Huang, Enguo Ju, Zhen Liu, Meili Yin, Jinsong Ren, Xiaogang Qu
https://www.researchgate.net/publication/312564723_Current_Multistage_Drug_Delivery_Systems_Based_on_the_Tumor_Microenvironment
Recently, multistage drug delivery systems (Ms-DDS) triggered by various specific tumor microenvironment stimuli have emerged for tumor therapy and imaging. In response to the differences in the physiological blood circulation, tumor microenvironment,...
https://pubs.acs.org/doi/10.1021/acsami.8b14009
Capitalizing on the recognition capability and biocompatibility of aptamers, we herein designed a multistage targeted drug-delivery system using multiple biodegradable molecules-enveloped nanovehicle that can be employed to efficiently treat human epithelial growth …Author: Tingxizi Liang, Zhigang Yao, Jie Ding, Qianhao Min, Liping Jiang, Jun-Jie Zhu
https://www.sciencedirect.com/science/article/pii/S1043661816308143
The major difference between the enzyme-stimulated multistage vector (ESMSV) and the majority of previously reported enzyme-responsive drug delivery platforms is the location of drug release. While the ESMSV increases tumor-specific exposure to drugs, the drug release process does not take place in the extracellular environment, as MMPs target the bond between nanoparticles and microparticles.Author: Yu Mi, Joy Wolfram, Joy Wolfram, Chaofeng Mu, Xuewu Liu, Elvin Blanco, Haifa Shen, Haifa Shen, Mauro...
http://europepmc.org/patents/PAT/WO9423705
A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) for containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16).
https://onlinelibrary.wiley.com/doi/10.1002/adma.201201498
Multistage pH‐Responsive Liposomes for Mitochondrial‐Targeted Anticancer Drug Delivery Ran Mo Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. ChinaAuthor: Ran Mo, Qiong Sun, Jingwei Xue, Nan Li, Wenyuan Li, Can Zhang, Qineng Ping
https://www.pnas.org/content/108/6/2426
Feb 08, 2011 · Multistage nanoparticle systems provide additional tunability in the spatial control of delivery to solid tumors. Because of the multiple physiological barriers that a therapeutic agent must encounter, a multistage nanoparticle system can enhance penetration by changing its size, charge, shape, flexibility, and/or surface coating to suit the transport across each barrier.Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
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