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https://www.pnas.org/content/108/6/2426
Feb 08, 2011 · We used quantum dots (QD) as a model system for the 10-nm particles because their fluorescence can be used to demonstrate the validity of our approach. In vitro MMP-2 activation of the multistage nanoparticles revealed that the size change was efficient and effective in the enhancement of diffusive transport.Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801423
Herein, we present a nanoparticle‐based delivery system that can achieve multistage delivery of CRISPR/dCas9 system in vivo via intravenous administration and induce the transcriptional activation of the tumor suppressor gene miR‐524 in cancer cells. The multistage delivery nanoparticle ...Author: Qi Liu, Kai Zhao, Chun Wang, Zhanzhan Zhang, Chunxiong Zheng, Yu Zhao, Yadan Zheng, Chaoyong Liu, Yi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327631/
Jan 07, 2017 · The development of traditional tumor-targeted drug delivery systems based on EPR effect and receptor-mediated endocytosis is very challenging probably because of the biological complexity of tumors as well as the limitations in the design of the functional nano-sized delivery systems. Recently, multistage drug delivery systems (Ms-DDS ...Author: Binlong Chen, Wenbing Dai, Bing He, Hua Zhang, Xueqing Wang, Yiguang Wang, Qiang Zhang
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201807294
In this study, a multistage delivery system capable of reversing hypoxia is demonstrated. Unlike previous strategies that only expect to affect the peripheral tumor tissue, the size‐shrinkable system allows those deeply located hypoxia regions to be treated.Author: Donglin Xia, Donglin Xia, Peipei Xu, Xingyu Luo, Jianfeng Zhu, Haiying Gu, Da Huo, Yong Hu
https://www.pnas.org/content/pnas/108/6/2426.full.pdf
Multistage nanoparticle delivery system for deep penetration into tumor tissue Cliff Wonga, Triantafyllos Stylianopoulosb, Jian Cuia, John Martinb, Vikash P. Chauhanb, Wen Jiangb, Zoran Popovic´a, Rakesh K. Jainb, Moungi G. Bawendia,1, and Dai Fukumurab,1 aDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; and bEdwin L. Steele Laboratory for Tumor Biology ...Author: Cliff Wong, Triantafyllos Stylianopoulos, Jian Cui, John Daniel Martin, Vikash P. Chauhan, Wen Jiang...
https://www.nature.com/articles/nnano.2008.34
Mar 02, 2008 · The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system …Author: Ennio Tasciotti, Xuewu Liu, Rohan Bhavane, Kevin Plant, Ashley D. Leonard, B. Katherine Price, Mark ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325604/
Jan 09, 2019 · a) Schematic illustration for the preparation of MDNP and delivery process after intravenous injection. b) Multistage delivery of CRISPR/dCas9 system from blood circulation to tumor cells via MDNP. Stage 1: MDNP maintains stable during circulating in bloodstream.Author: Qi Liu, Kai Zhao, Chun Wang, Zhanzhan Zhang, Chunxiong Zheng, Yu Zhao, Yadan Zheng, Chaoyong Liu, Yi...
https://www.researchgate.net/publication/257688991_Multifunctional_to_multistage_delivery_systems_The_evolution_of_nanoparticles_for_biomedical_applications
a multistage delivery system for imag ing and therapeutic applications. Nat Nanotechnol, 2008, 3: 151–157 63 Sakamoto J, Annapragada A, Decuzz i P, et al. Antibiological barrier
https://briefs.techconnect.org/wp-content/volumes/Nanotech2010v3/pdf/1692.pdf
We developed a novel hybrid biomimetic delivery system that combines together the characteristics of an artificial multistage delivery system with the physiologic components that trigger the natural ability of leukocytes (T and B cells) to transmigrate from the blood stream to the tumor site. Keywords: nanoparticles, delivery system, leukocytes,Author: N. Quattrocchi, C. Chiappini, Laurence Cooper, M. Ferrari, M. Ferrari, M. Ferrari, E. Tasciotti
https://www.researchgate.net/publication/44644543_Cellular_Association_and_Assembly_of_a_Multistage_Delivery_System
The realization that blood-borne delivery systems must overcome a multiplicity of biological barriers has led to the fabrication of a multistage delivery system (MDS) designed to temporally ...
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