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https://www.researchgate.net/publication/45437242_Monolithic_Controlled_Delivery_Systems_Part_I_Basic_Characteristics_and_Mechanisms
Monolithic Controlled Delivery Systems: Part I. Basic Characteristics and Mechanisms. The article considers contemporary systems for controlled delivery of active agents, such as drugs, agricultural chemicals, pollutants and additives in the environment.
https://www.nature.com/articles/pj1991133
Sep 01, 1991 · Conventional monolithic drug delivery devices in which drug is uniformly dispersed typically show square-root-of-time release rates. To achieve zero-order release, monolithic devices …Author: Ryo Yoshida, Kiyotaka Sakai, Teruo Okano, Yasuhisa Sakurai
https://link.springer.com/chapter/10.1007/978-1-4757-4175-9_18
Abstract. Controlled drug release from monolithic systems can be achieved by diffusion, swelling, or erosion. In diffusion-controlled systems the drug is dissolved or dispersed in a polymer matrix and allowed to diffuse from the monolith. In swelling-controlled systems the drug is immobilized in a glassy, hydrophilic polymer...Author: J. Heller
https://patents.google.com/patent/US20100068169A1/en
This invention relates to an improved monolithic drug delivery dosage form which releases a pharmaceutically active agent at a predetermined rate. The dosage form comprises a salted-out or crosslinked polymer and a pharmaceutically active agent.Author: Sibongile Ruth Sibambo, Viness Pillay, Yahya Essop Choonara
https://pdfs.semanticscholar.org/db20/12b6ea9ff4e7e06574a3a4a6317a15e9fce0.pdf
DESIGN AND EVALUATION OF MONOLITHIC DRUG-IN- ... Transdermal drug delivery (TDD) is a promising method to administer the drug to ... potential route for the local and systemic delivery of drugs (Ranade 1991) as it provides controlled release of the drug, and produces a steady blood-level profile, leading to reduced systemic side effects and ...
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