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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
The major challenge of miRNA delivery into cancer is to successfully deliver miRNA antagonists or miRNA mimics to the target tumor tissue with efficient penetration of cargos into the tumor. The leaky structure and compression of abnormal tumor vessels lead to poor blood perfusion, which reduces the delivery efficacy of naked miRNAs [ 61 ] ( Fig. 2 ).Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
The major challenge of miRNA delivery into cancer is to successfully deliver miRNA antagonists or miRNA mimics to the target tumor tissue with efficient penetration of cargos into the tumor. The leaky structure and compression of abnormal tumor vessels lead to poor blood perfusion, which reduces the delivery efficacy of naked miRNAs .Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
In fact, in the single clinical trial reported for RNAi delivery to brain tumor (which targeted tenancin-C), the siRNA was injected directly into infiltrative (inoperable) regions of brain tumor [ 11 ].Author: Saroj P Mathupala
https://onlinelibrary.wiley.com/doi/10.1002/advs.201903290
Jan 20, 2020 · To realize efficient microRNAs delivery to GICs through the CXCR4‐stimulated macropinocytosis pathway, a drug‐delivery system for efficient microRNAs loading and release is essential. Lipoproteins, natural nanostructures possessing favorable surface properties with an extended period in the circulation, are suitable for delivering therapeutic agents.Author: Gan Jiang, Huan Chen, Huan Chen, Jialin Huang, Qingxiang Song, Yaoxing Chen, Xiao Gu, Zhenhuan Jiang...
https://www.sciencedirect.com/science/article/pii/S0168365919306492
In previous studies, delivery of antisense miRNA oligonucleotides against miR-21 (AMO-21) has efficiently reduced brain tumors by intratumoral injection with a proper carrier [11,12]. However, direct injection of therapeutics into the brain is an invasive procedure and may induce damage.Author: Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung Lee
https://www.physiology.org/doi/pdf/10.1152/ajplung.00423.2016
mimic(s) or inhibitor(s) to the recipient cells. Delivery of these miRNA molecule enriched-exosomes subsequently results in highly efficient overexpression or deletion of the designated miRNAs in the recipient cells both in vivo and in vitro. Additionally, we confirmed that exosome-delivered miRNA mimics or inhibitors are functional inAuthor: Duo Zhang, Heedoo Lee, Ziwen Zhu, Jasleen K. Minhas, Yang Jin
https://www.nature.com/articles/s41551-017-0157-y
Nov 27, 2017 · An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in …Author: Leo L. Wang, Ying Liu, Jennifer J. Chung, Tao Wang, Ann C. Gaffey, Minmin Lu, Christina A. Cavanaugh...
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.biostandups.com/bio-news/new-mode-mirna-delivery-flat-worm-sheds-light-brain-organisation/
In one such instance, successful delivery of nucleic acids, microRNAs and anti-miRNAs has enabled this team to identify the role of the microRNA, miR-124, in regulating the fate of neural subtypes and eye progenitors. This microRNA is also shown to be closely involved in regulating the size of the brain and the photoreceptors, during the ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0461-7
Feb 19, 2019 · Background Accumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However, safe and efficient delivery of miR-210 via intravenous administration is still a challenge. In the past decade, exosomes have emerged as a novel endogenous delivery system.Author: Huixin Zhang, Jin Wu, Jiahuan Wu, Qi Fan, Jingchao Zhou, Junwen Wu, Sichen Liu, Jie Zang, Jinhai Ye,...
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