We have collected information about Mirna Drug Delivery for you. Follow the links to find out details on Mirna Drug Delivery.
https://www.ddw-online.com/therapeutics/p322575-current-trends-in-rna-therapeutics-development.html
Both miRNA inhibitors and mimics are currently being developed and have shown encouraging results (10). For example, RG-012 (Regulus Therapeutics Inc) is a miRNA drug currently being evaluated in Phase I trials for the treatment of Alport syndrome (11). siRNA
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The attitude of big pharmaceutical companies to RNAi drugs has also become over-optimistic. In summary, a good delivery system is the key to siRNA drug development. Once research into siRNA drug delivery systems makes a significant breakthrough, siRNA will occupy a strong position in the drug market, especially the anti-cancer drug market.Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/nrd.2016.246
Feb 17, 2017 · Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I …Author: Rajesha Rupaimoole, Frank J. Slack
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0734975017300204
Advances in the understanding of microRNA (miRNA) functions and the ideal properties of nanosystems have brought increasing attention to the application of nanomedicine to cancer therapy. This review covers the different miRNA therapeutic strategies and delivery challenges for its application in …Author: I. Fernandez-Piñeiro, I. Badiola, A. Sanchez
https://www.europeanpharmaceuticalreview.com/news/81549/drug-delivery-mirna-vesicles/
Nov 21, 2018 · “Extracellular vesicles and exosomes, in particular, have been of interest as drug delivery vehicles but their use to deliver miRNAs has been hampered by difficulties associated with loading miRNAs into exosomes,” said WFIRM Director Dr Anthony Atala, who is a co-author of the paper. “Other methods are inefficient and incompatible with ...
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in vivo cargo delivery.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Mounting evidence suggests that miRNA-based therapies, either restoring or repressing miRNAs expression and activity, hold great promise. However, despite the early promise and exciting potential, critical hurdles often involving delivery of miRNA-targeting agents remain to be overcome before transition to clinical applications.Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30190-7
This drug can be used with an extensive variety of cancers, such as colon cancer, non-small-cell lung cancer (NSCLC), hepatocellular carcinoma, cervical cancer, and ovarian cancer. Mirna Therapeutics is the biopharmaceutical company that is performing the MRX34 phase 1 …Author: Chiranjib Chakraborty, Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C. George Priya D...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0563-2
More excitedly, the combinational delivery of miR-21i and 5-FU with the engineered exosomes effectively reverse drug resistance and significantly enhanced the cytotoxicity in 5-FU-resistant colon cancer cells, compared with the single treatment with either miR-21i or 5-FU.
Searching for Mirna Drug Delivery?
You can just click the links above. The data is collected for you.
