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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251455/
Nov 20, 2018 · Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivoAuthor: Zahra Naseri, Reza Kazemi Oskuee, Mahmoud Reza Jaafari, Mehdi Forouzandeh Moghadam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180003/
Interestingly, in our study, the B cell-derived exosomes mediated effective delivery of miRNA-155 inhibitor and caused post-transcriptional gene knockdown (TNFα) in the recipient cells. miRNA-155 mimic loaded exosomes significantly increased miRNA-155 levels in primary mouse hepatocytes and the liver of miRNA-155 knockout mice.Author: Fatemeh Momen-Heravi, Shashi Bala, Terence N. Bukong, Gyongyi Szabo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502074/
One of that is exosomes are natural carriers of biological information in the form of miRNA and can deliver miRNA content to specific cell types via receptor-mediated binding. Secondly, exosomes are rapidly taken up by recipient cells, therefore minimal off-target effects are …Author: Prabhu Mathiyalagan, Susmita Sahoo
https://www.exosome-rna.com/delivery-of-exosomal-mirnas-in-vitro-and-in-vivo/
Nov 28, 2016 · Delivery of these miRNA molecule enriched-exosomes subsequently results in highly efficient over-expression or deletion of the designated miRNAs in the recipient cells both in vivo and in vitro. Additionally, the researchers confirmed that exosome-delivered miRNA …
https://www.ncbi.nlm.nih.gov/pubmed/27910046
Exosomes, unlike other vectors for gene delivery, present unique advantages such that exosomes are a cell-free natural system for ferrying RNA between cells, robust exosomal membrane can protect the RNA/gene of interest from digestion, and exosomes are rapidly taken up by target cells making them a more efficient vehicle for gene delivery.Author: Prabhu Mathiyalagan, Susmita Sahoo
https://www.sciencedirect.com/science/article/pii/S2162253117301609
Targeted miRNAs delivery for amplification of neurogenesis is promising in promoting the prognosis after ischemia. Here, we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane glycoprotein 2b (Lamp2b), could efficiently deliver miR-124 to the infarct site.Author: Jialei Yang, Jialei Yang, Xiufen Zhang, Xiangjie Chen, Lei Wang, Guodong Yang
https://www.exosome-rna.com/exosome-based-gene-therapy-for-microrna-delivery/
Dec 08, 2016 · Recent findings by researchers at the Icahn School of Medicine unveiled a novel mechanism that exosomes, secreted nanovesicles from stem cells, mediate cardiac repair via transferring their unique repertoire of microRNAs (miRNA) to recipient cells in the heart. Exosomes, unlike other vectors for gene delivery, present unique advantages such that exosomes are a cell-free natural system for ferrying RNA between cells, robust exosomal membrane …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851954/
Apr 06, 2010 · We proposed that EBV-miRNAs may function outside infected B cells by exosome-mediated delivery into physiologically relevant recipient cells. Dendritic cells (DC) control T-cell–mediated immunity of EBV infection and control EBV-driven transformation (21, 22).Author: D. Michiel Pegtel, Katherine Cosmopoulos, David A. Thorley-Lawson, Monique A. J. van Eijndhoven, Eri...
https://www.sciencedirect.com/science/article/pii/S1818087617304609
MiRNA has a capacity to reduce fibrosis by modulating targets associated with collagen and extracellular matrix accumulation [ 83 ]. Therefore, exosome mediated delivery of miRNA may provide great promise for the treatment of kidney fibrosis.Author: Mei Lu, Haonan Xing, Zhe Xun, Tianzhi Yang, Pingtian Ding, Cuifang Cai, Dongkai Wang, Xiaoyun Zhao
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Here we show how exosomes derived from cultured cells can be harnessed for delivery of siRNA in vitro and in vivo. This protocol first describes the generation of targeted exosomes …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
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