We have collected information about Mirna Mimic In Vivo Delivery for you. Follow the links to find out details on Mirna Mimic In Vivo Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
The major challenge of miRNA delivery into cancer is to successfully deliver miRNA antagonists or miRNA mimics to the target tumor tissue with efficient penetration of cargos into the tumor. The leaky structure and compression of abnormal tumor vessels lead to poor blood perfusion, which reduces the delivery efficacy of naked miRNAs [ 61 ] ( Fig. 2 ).Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.researchgate.net/post/Does_anyone_know_how_to_deliver_miRNA-mimic_ex_vivo
To ensure the mimics are actually getting into the tissue, I performed pilot experiments with fluorescent tagged mimics to visualize where and if the mimic was getting into the cells. I only culture my organs for 6 days and treat them with two doses of the mimics (day 1 and day 4 of culture).
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
The major challenge of miRNA delivery into cancer is to successfully deliver miRNA antagonists or miRNA mimics to the target tumor tissue with efficient penetration of cargos into the tumor.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.hindawi.com/journals/ije/2019/6782653/
Thus, LVs are more frequently used as in vivo miRNA delivery vectors to improve bone metabolism and promote bone regeneration.Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://www.physiology.org/doi/pdf/10.1152/ajplung.00423.2016
Enrichment of selective miRNAs in exosomes and delivery of exosomal. miRNAs in vitro and in vivo. Duo Zhang,1* Heedoo Lee,1* Ziwen Zhu,1 Jasleen K. Minhas,2 and Yang Jin1. 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, Massachusetts;Author: Duo Zhang, Heedoo Lee, Ziwen Zhu, Jasleen K. Minhas, Yang Jin
https://www.sciencedirect.com/science/article/pii/S1525001617301648
In this report, we demonstrate an effective microRNA delivery system in the form of NCPs carrying oligometastases-associated 14q32-encoded miR-655-3p in an experimental model of colorectal hepatic metastases that was quantifiable through in vivo bioluminescence and ex vivo fluorescence. 8 Our results suggest that an NCP-based microRNA delivery system can be used as a potential …Author: Go Oshima, Nining Guo, Chunbai He, Melinda E. Stack, Christopher Poon, Abhineet Uppal, Sean C. Wight...
https://www.nature.com/articles/ncomms12868
Sep 19, 2016 · An in vivo experiment showed that the use of nanoparticles embedded in a hydrogel scaffold as a miRNA delivery vehicle enables an efficient and specific delivery of miR-96/miR-182 …Author: Avital Gilam, João Conde, João Conde, Daphna Weissglas-Volkov, Nuria Oliva, Eitan Friedman, Natalie ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · There is such overlap that miRNA delivery, particularly when double-stranded approximately 21 nt sequences are delivered, that the terminology si (mi)RNA or simply siRNA is recommended by some [ 23 ]. Although the similarity in at least one mechanism of action may be true, we propose the difference between siRNA...Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=14264&path%5B%5D=47602
For in vivo delivery, miRNA was incorporated into pegylated liposomes composed of dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and pegylated distearoyl-phosphatidylethanolamine (DSPE-PEG-2000) (Avanti Lipids). DMPC and DSPE-PEG2000 were mixed at a 10:1 ratio, and miRNA (control or miR-603 mimic, 8ug miR/mouse) was mixed at a 10:1 (w/w) ratio ...Author: Recep Bayraktar, Recep Bayraktar, Martin Pichler, Pinar Kanlikilicer, Cristina Ivan, Emine Bayraktar...
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