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https://www.researchgate.net/publication/262611368_In_Vivo_Delivery_of_miRNAs_For_Cancer_Therapy_Challenges_and_Strategies
The major challenges of miRNA-based therapy involve the multitude of targets for each miRNA as well as the delivery route of miRNA biologics (Chen et al., 2015). Oral or intravenous delivery will ...
https://www.gastrojournal.org/article/S0016-5085(10)00088-0/fulltext
MiRNA delivery can be achieved using viral and nonviral approaches. The main purpose of viral vectors is to maintain long-term and consistent gene modulation, whereas nonviral approaches are probably safer because of their lower immunogenicity in humans.
https://molcelltherapies.biomedcentral.com/articles/10.1186/2052-8426-2-7
miRNA delivery systems. Beside chemical modification of miRNAs to avoid rapid degradation and excretion, the development of improved delivery systems leads to enhanced stability and more precise delivery of miRNAs. miRNAs can be conjugated to a cholesterol moiety, increasing stability in the circulation and facilitating cell entry . A further mechanism of protection is to enclose miRNA mimics or …
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · In addition to siRNA, many studies have been carried out on the roles of miRNA and shRNA in cancer therapy. Human cancer was recently associated with changes in miRNA profile , drawing even more attention to the nanocarrier-based delivery of miRNA.
https://www.exosome-rna.com/exosome-based-gene-therapy-for-microrna-delivery/
Dec 08, 2016 · Exosome-Based Gene Therapy for MicroRNA Delivery Posted by: Exosome RNA Administrator in Methods December 8, 2016 0 2,695 Views Despite recent advances in scientific knowledge and clinical practice, cardiovascular disease management and treatment remain a …
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801809
Jan 15, 2019 · Second, although vitamin A has been used as a targeting ligand for HSC‐targeted siRNA delivery, 54 the strategy has not been applied in miRNA therapy yet. Third, the miRNA therapy integrating pH‐sensitive miRNA release, HSC‐targeted miRNA delivery, and MRI monitoring has not been reported so far.
https://www.researchgate.net/publication/321929807_MiRNA_delivery_for_skin_wound_healing
A significant obstacle to the miRNA-based treatments is the efficient delivery of miRNA to the target tissue. We have developed polyethylene glycol-modified liposomes (Bubble liposomes (BLs)) that...
https://mirnablog.com/microrna-delivery-by-nanoparticles/
Two groups have recently published results of microRNA delivery by nanoparticles. The first group, at University of California San Diego 1, identified miR-132 as a highly upregulated miRNA in a human embryonic stem cell model of vasculogenesis and showed that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducing …
https://www.sciencedirect.com/science/article/pii/S0168365913008031
There is such overlap that miRNA delivery, particularly when double-stranded approximately 21 nt sequences are delivered, that the terminology si(mi)RNA or simply siRNA is recommended by some . Although the similarity in at least one mechanism of action may be true, we propose the difference between siRNA and miRNA to be the intent to knock down an individual mRNA with siRNA and an …
https://www.mdpi.com/2073-4409/9/2/521/pdf
cells Review Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy Clodagh P. O’Neill 1 and Róisín M. Dwyer 1,2,* 1 Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, H91 YR71 Galway, Ireland; [email protected]
https://www.nature.com/articles/gt201150
Apr 28, 2011 · Such miRNA decoys could provide an inexpensive alternative to proprietary oligonucleotide chemistries and delivery formulations, enabling research laboratories to examine the consequence of...
https://www.sciencedirect.com/science/article/pii/S2162253116300373
siRNA Versus miRNA as Therapeutics for Gene Silencing. ... early generation polymers studied for nucleic acid delivery. 129 It is the most widely investigated polymer for siRNA and miRNA delivery in vivo. 130, 131 Because of its high transfection efficiency, ... , 116 and the latter are employed in miRNA replacement therapy for the treatment of ...
https://medicalxpress.com/news/2017-08-cancer-therapy-toxic-delivery-vehicles.html
Aug 02, 2017 · By linking miRNA to folate scientists, specifically delivered therapeutics to tumors without the need for delivery vehicles. Credit: E.A. Orellana et al., Science Translational Medicine (2017)
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles are perhaps ...
http://rnai.technology/rnai-type/top-rani-gene-therapy-companies/
Top RNAi and gene therapy companies, ddRNAi, DNA vaccines
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