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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
Thus, many groups have worked on overcoming those hurdles to achieve safe, specific and efficient miRNA therapy. Several carrier systems and delivery strategies were developed to solve the problems that arise during In vivo delivery of miRNAs for treating cancer.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.researchgate.net/publication/270002235_Lipid-based_mRNA_vaccine_delivery_systems
Lipid-based mRNA vaccine delivery systems Article (PDF Available) in Expert Review of Vaccines 14(2):1-14 · December 2014 with 1,926 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674998/
Viral and nonviral miRNA delivery systems have both advantages and disadvantages: Viral vectors produce higher transfection efficiency but are more toxic and immunogenic, whereas nonviral carriers have lower delivery efficiency but are much safer. Therefore, effective and safe miRNA delivery systems are in urgent need.
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
A few polymer-based siRNA delivery systems have shown therapeutic potential in clinical trials . Examples of major classes of polymer-based delivery systems are discussed below. 7. siRNA-polymer bioconjugates. Direct conjugation of siRNA to polymers offers an attractive avenue to improve stability, pharmacokinetics, cellular uptake, and delivery.Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.sciencedirect.com/science/article/pii/S0169409X17303149
The moist and protected micro-environment in addition to the efficacious delivery of the miRNA are key points of the therapeutics. To date, various non-viral delivery systems for miRNA delivery have been developed and proven effective, including liposomes, cationic …Author: Zhao Meng, Dezhong Zhou, Yongsheng Gao, Ming Zeng, Wenxin Wang
https://www.hindawi.com/journals/ije/2019/6782653/
5.2.3. Other Nonviral miRNA Delivery Systems. Liu et al. fabricated a nonviral miRNA delivery method based on nanocapsules, which are neutrally charged and size-homogeneous with enhanced miRNA stability and high transfection efficiency and can release the miRNAs once inside cells. The nanocapsules were synthesized by in situ polymerization.Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://www.nature.com/articles/s41551-017-0157-y
Nov 27, 2017 · Our findings suggest that biomaterial-based miRNA delivery systems can lead to improved outcomes via cardiac regeneration after myocardial infarction. An …Author: Leo L. Wang, Ying Liu, Jennifer J. Chung, Tao Wang, Ann C. Gaffey, Minmin Lu, Christina A. Cavanaugh...
https://www.researchgate.net/publication/321929807_MiRNA_delivery_for_skin_wound_healing
Meanwhile, non-viral miRNA delivery systems, such as cationic polymers, peptides, and liposomes, are recognized by their lower toxicity, water solubility, and resistance to endonucleases or ...
https://pubs.acs.org/doi/full/10.1021/acsomega.8b03562
Viral vectors are efficient delivery agents but toxicity and immunogenicity limit their clin. usage. Herein, we review the recent advances in the mechanisms and strategies of nonviral miRNA delivery systems and provide a perspective on the future of miRNA-based therapeutics.Author: Anna-Laurence Schachner-Nedherer, Oliver Werzer, Andreas Zimmer
https://www.genengnews.com/magazine/153/mirna-rnai-delivery-and-applications/
Mar 01, 2011 · They discuss topics ranging from recent advances and novel applications to improved delivery systems. We trust that you will find this issue of GEN’s Tech Tips extremely useful in your own miRNA ...
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