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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Herein, we review the recent advances in the mechanisms and strategies of nonviral miRNA delivery systems and provide a perspective on the future of miRNA-based therapeutics. Keywords: microRNA, miRNA therapeutics, small RNA delivery, human disease, nonviral deliveryAuthor: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://pubs.acs.org/doi/10.1021/mp2002076
However, miRNA-based therapy is faced with several challenges including lack of tissue specificity, lack of optimal delivery systems, poor cellular uptake and risk of systemic toxicity. Here, we report a cationic lipid based miRNA delivery system to address some of these challenges.Author: Yun Wu, Melissa Crawford, Bo Yu, Yicheng Mao, Serge P. Nana-Sinkam, L. James Lee
https://www.researchgate.net/publication/321929807_MiRNA_delivery_for_skin_wound_healing
In this review, we will discuss the special considerations for miRNA delivery for cancer therapy, focusing on nonviral delivery systems: lipid, polymeric, and inorganic nanocarriers. View Show ...
https://www.sciencedirect.com/science/article/pii/S0168365919305796
This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application ...Author: Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Tatsuya Osaki, Giulia Adriani, ...
https://www.sciencedirect.com/science/article/pii/S0169409X17303149
What's more, miRNAs expression can be efficiently inhibited both in vitro and in vivo. So, the enthusiasm about the therapeutic potential of miRNA in wound healing has been triggered by manipulating miRNAs expression through the delivery of miRNAs inducers or inhibitors . Diverse miRNAs play obviously different roles in the different phases of ...Author: Zhao Meng, Dezhong Zhou, Yongsheng Gao, Ming Zeng, Wenxin Wang
https://www.nature.com/articles/nrd.2016.246
Feb 17, 2017 · This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic. ... of identifying the most efficacious ...Author: Rajesha Rupaimoole, Frank J. Slack
https://www.nature.com/articles/nrm3838
Jul 16, 2014 · Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging. ... This Review summarizes our current understanding of how miRNAs are made ...Author: Minju Ha, V. Narry Kim
https://www.researchgate.net/publication/309027511_Biomaterials_in_siRNA_Delivery_A_Comprehensive_Review
In this review, we will present the strategies for intracellular miRNAs delivery, and specially focuse on the rational designed routes, their mechanisms of action, as well as potential therapeutic ...
https://www.hindawi.com/journals/ije/2019/6782653/
Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations.Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
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