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https://mirnablog.com/microrna-delivery-by-nanoparticles/
They designed a nanoparticle that’s capable of delivering the microRNA (miR-132) or the anti-microRNA directly to diseased or proliferating blood vessels. This delivery vehicle ensures the therapeutic benefit is maximized while reducing the possibility of toxicity or side effects.
https://www.sciencedirect.com/science/article/pii/S0168365919305796
On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration.Author: Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Tatsuya Osaki, Giulia Adriani, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
Inorganic nanoparticles-based miRNA delivery Lately, inorganic materials such as gold, carbon and silica are used to compose a non-viral gene delivery system with controlled size and morphology. The unique physical and chemical properties of inorganic nanoparticles offer potential for development of a biocompatible, non-immunogenic and non-toxic delivery system, which is also easier to scale up …Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://link.springer.com/protocol/10.1007%2F978-1-4939-7138-1_14
Jul 21, 2017 · To overcome challenges with in vivo delivery of microRNAs related to stability, cellular uptake, and specific delivery, our group has developed and characterized chitosan nanoparticles for nucleotide delivery. This platform allows for robust target modulation and antitumor activity following intravenous administration.Author: Merve Denizli, Burcu Aslan, Lingegowda S. Mangala, Dahai Jiang, Cristian Rodriguez-Aguayo, Gabriel L...
https://pubs.rsc.org/en/content/articlelanding/2020/bm/d0bm00015a
It has been acknowledged that miR-34a is down-regulated and miR-10b is up-regulated in TNBC which promotes tumorigenesis and metastatic dissemination. However, there are few barriers related with miRNA delivery. Herein, we have introduced a tailored mesoporous silica nanoparticle (MSN) for co-delivery of miR-34a-mimic and antisense-miR-10b.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956805/
Jan 01, 2020 · PL1/miR-9 nanoparticles revealed a specifically targeted delivery ability and penetrability. Previously, we have established a chimeric peptide supramolecular nanoparticle for plectin-1 targeted PDAC-specific miRNA delivery system 21.Author: Ying Wu, Yuexiao Tang, Shangzhi Xie, Xiaoxiao Zheng, Shufen Zhang, Jiayan Mao, Baoming Wang, Yuerou ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0368-8
Apr 13, 2018 · Like animals, the RNA nanoparticle based miRNA delivery technique can be utilised in plants to target those biotic and abiotic stresses against which there is no effective strategy for combating them. RNA nanotechnology may revolutionize the crop improvement programmes which will be a step towards food security worldwide.Author: Vrantika Chaudhary, Sumit Jangra, Neelam R. Yadav
https://www.nature.com/articles/srep46250
Apr 07, 2017 · PLGA-based dual targeted nanoparticles enhance miRNA transfection efficiency in hepatic carcinoma ... L. C., Shohet, J. M. & Gunaratne, P. H. A gold nanoparticle platform for the delivery …Author: Chenlei Cai, Yuexia Xie, liangliang Wu, Xiaojing Chen, Hongmei Liu, Yan Zhou, Hanbing Zou, Dejun Liu...
https://www.sciencedirect.com/science/article/pii/S0168365916307842
The self-immolative polymer nanoparticles show great promise as dual-function delivery vectors of therapeutic miRNA, providing a novel, simple and elegant approach to the design of combination nanomedicines for cancer treatment.Author: Ying Xie, Tracy Murray-Stewart, Yazhe Wang, Fei Yu, Jing Li, Laurence J. Marton, Robert A. Casero, D...
https://www.longdom.org/open-access/nanoparticle-based-delivery-of-mirnas-to-overcome-drug-resistance-inbreast-cancer-2157-7439-1000414.pdf
Nanoparticles based drug delivery systems that have been designed to enhance delivery of therapeutics to tumors, are a novel approach. Nanoparticles have reactive surface that can be readily modified with biocompatible coatings and loaded with therapeutic agents (miRNA, siRNA, antibody, anti-cancer drug etc..). MicroRNAs (miRNAs or miRs) areAuthor: Serap Yalcin, Gunduz U
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