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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
In addition to applications in the skin, microneedles have also been used for drug delivery to the eye. In the first study of ocular drug delivery, coated microneedles were used to administer model compounds into the sclera and corneal stroma . Administration of pilocarpine to the corneal stroma in this way achieved a bioavailablity almost two orders of magnitude greater than topical delivery and induced …Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.amazon.com/Microneedles-Vaccine-Delivery-Patient-Monitoring/dp/1119305144
Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.Author: Ryan F. Donnelly
https://www.ncbi.nlm.nih.gov/pubmed/22575858
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12001251
Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety.Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119305101
Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.
https://www.amazon.com/Microneedles-Vaccine-Delivery-Patient-Monitoring-ebook/dp/B07DJYM8C9
Microneedles for Drug and Vaccine Delivery and Patient Monitoring - Kindle edition by Ryan F. Donnelly, Thakur Raghu Raj Singh, Eneko Larrañeta, Maeliosa T.C. McCrudden. Download it once and read it on your Kindle device, PC, phones or tablets.
https://www.sciencedirect.com/science/article/pii/S0169409X12001251
In addition to applications in the skin, microneedles have also been used for drug delivery to the eye. In the first study of ocular drug delivery, coated microneedles were used to administer model compounds into the sclera and corneal stroma . Administration of pilocarpine to the corneal stroma in this way achieved a bioavailability almost two orders of magnitude greater than topical delivery and induced …Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.researchgate.net/publication/224939166_Microneedles_for_Drug_and_Vaccine_Delivery
For the targets for vaccine delivery [71, 77], the skin is a first line of defense against pathogen entry into the body and, therefore, has abundant populations of immune cells. Microneedles are measuring hundreds of microns to target the skin, which have 1-2 mm thick at typical administration sites. ...
https://onlinelibrary.wiley.com/doi/10.1002/9781119305101.ch10
Jun 22, 2018 · MNs were developed as a painless, minimally invasive and effective technology for transdermal drug delivery. MN application to the eye could offer several advantages over invasive intraocular injections that utilise long, conventional, hypodermic needles.Author: Ismaiel A. Tekko, Ismaiel A. Tekko, Thakur Raghu Raj Singh
https://www.ondrugdelivery.com/simplified-drug-vaccine-delivery-using-microns-microneedle-patch/
Microneedles are micron-sized structures that encapsulate a drug or vaccine and are designed to create pathways into the skin to deliver actives into the epidermis and/or dermis by employing a simple-to-use patch applied to the skin.
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