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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
Images of microneedles used for transdermal drug delivery. (a) Solid microneedles (150 μm tall) etched from a silicon wafer were used in the first study to demonstrate microneedles for transdermal delivery. (b) Solid microneedles (1000 μm tall) laser-cut from a stainless steel sheet were used to …Author: Mark R Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X12001251
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/microneedle/
3M Microneedle Drug Delivery Systems, which include Hollow Microneedle and Solid Microneedle technology, offer patient-friendly delivery solutions for vaccines or difficult-to-deliver biologics for particularly needle-phobic patients. By potentially reducing anxiety, microneedle delivery may improve patient compliance in some patient groups.
https://www.ncbi.nlm.nih.gov/pubmed/22575858
Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Expert opinion: In past years, there has been a crescent of advances in the development of microneedles as a drug delivery system by researchers and pharmaceutical companies. The authors observed patents related to manufacture of dissolving, hydrogel-forming, solid, hollow and coated microneedles for ocular and transdermal drug delivery.
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