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https://www.sciencedirect.com/science/article/pii/S0753332218348091
Combination of ultrasound and transdermal drug delivery is also studied in order to further increase the drug permeability . Thus, microneedles can be fabricated with a variety of modifications in order to smartly deliver the drug through the skin providing a new direction and revolution in the field of transdermal drug delivery systems.Author: Tejashree Waghule, Gautam Singhvi, Sunil Kumar Dubey, Murali Monohar Pandey, Gaurav Gupta, Mahaveer ...
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/microneedle/
3M Microneedle Drug Delivery Systems, which include Hollow Microneedle and Solid Microneedle technology, offer patient-friendly delivery solutions for vaccines or difficult-to-deliver biologics for particularly needle-phobic patients. By potentially reducing anxiety, microneedle delivery may improve patient compliance in some patient groups.
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Advances in Drug Delivery by Microneedles. ... Transdermal drug delivery system is an emerging area for systemic as well as local delivery of macromolecules. The biggest drawback of TDDS is poor permeability through stratum corneum and it can be overcome by using microneedles. Hence, researchers focused their attention on development of ...Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990’s when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12001251
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906704/
Many promising therapeutic agents are limited by their inability to reach the systemic circulation, due to the excellent barrier properties of biological membranes, such as the stratum corneum (SC) of the skin or the sclera/cornea of the eye and others.The outermost layer of the skin, the SC, is the principal barrier to topically-applied medications.Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, A. David Woolfson
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Expert opinion: In past years, there has been a crescent of advances in the development of microneedles as a drug delivery system by researchers and pharmaceutical companies. The authors observed patents related to manufacture of dissolving, hydrogel-forming, solid, hollow and coated microneedles for ocular and transdermal drug delivery.
https://www.researchgate.net/publication/51860989_Microneedles_An_Emerging_Transdermal_Drug_Delivery_System
drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by c onventional transdermal techniques.
https://www.pharmatutor.org/pdf_download/pdf/Vol.%206,%20Issue%201,%20January%202018,%20PharmaTutor,%20Paper-1.pdf
Microneedles: an approach in transdermal drug delivery: a Review Devender Sharma Hi – Tech college of pharmacy, Chandrapur, Maharashtra, India [email protected] ABSTRACT Transdermal drug delivery carried out a promising carrier in the transport of drugs to get direct access across the skin deep into the systemic circulation.
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