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https://www.ncbi.nlm.nih.gov/pubmed/25233432
The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery system in the future.Author: Ana M. Villamil Giraldo, Hanna Appelqvist, Thomas Ederth, Karin Öllinger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664872/
Jan 06, 2009 · Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides allow efficient internalization of the linked cargos intracellularly through the endocytic pathway.Author: Ayman El-Sayed, Shiroh Futaki, Hideyoshi Harashima
https://portlandpress.com/biochemsoctrans/article/35/1/56/63989/Designing-polymer-conjugates-as-lysosomotropic
Jan 22, 2007 · Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they ...Author: R. Duncan
https://pubs.acs.org/doi/abs/10.1021/nn507382n
GNeosomes, lysosomotropic lipid vesicles decorated with guanidinoneomycin, can encapsulate and facilitate the cellular internalization and lysosomal delivery of cargo ranging from small molecules to high molecular weight proteins, in a process that is exclusively dependent on cell surface glycosaminoglycans. Their cellular uptake mechanism and co-localization with lysosomes, as well as the ...Author: Ezequiel Wexselblatt, Jeffrey D. Esko, Yitzhak Tor
https://www.youtube.com/watch?v=90vs3mzWe-o
Oct 20, 2016 · We have utilized the inherent tropism of nanocarriers towards the lysosomes for delivery of therapeutics for the delivery of drugs to these vesicles for treatment of Niemann Pick Type C-1, a ...Author: PrecisionNanoSystems
https://pubs.acs.org/doi/10.1021/mp300293n
Here we overview the endomembrane trafficking pathways, discuss the methods used to determine and quantitate the intracellular fate of nanomedicines, and review the current status of lysosomotropic and endosomotropic delivery.Author: Ruth Duncan, Simon C. W. Richardson
https://parikh.ucdavis.edu/publications/spontaneous-vesiculation-and-ph-induced-disassembly-lysosomotropic-detergent-impacts
Spontaneous vesiculation and pH-induced disassembly of a lysosomotropic detergent: impacts on lysosomotropism and lysosomal delivery: Ana María Villamil Giraldo, Timmy Fyrner, Stefan Wennmalm, Atul N. Parikh, Karin Ollinger, and Thomas Ederth Langmuir 32, 13566-13575 2016.
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