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https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201003144
we will focus on the localized delivery of siRNA to a target site. Delivery of Naked siRNA “Naked” siRNA delivery is the direct injection of a saline or excipient solution containing non-complexed siRNA se-quences to a target site. Generally, naked siRNA injected …
http://onlinelibrary.wiley.com/doi/10.1002/chem.201003144/abstract
Localized, Targeted, and Sustained siRNA Delivery ... The localized delivery of siRNA to a specific site in vivo is highly challenging. There are many disease states in which a systemic effect of RNAi may be desirable; some examples include non‐localized cancers, HIV, neurodegenerative diseases, respiratory viruses, and heart and vascular ...
https://www.researchgate.net/publication/49855355_Localized_Targeted_and_Sustained_siRNA_Delivery
Request PDF Localized, Targeted, and Sustained siRNA Delivery Short interfering RNA (siRNA) functions directly in the cytoplasm, where it is assembled into an RNA-induced silencing complex (RISC).
http://europepmc.org/abstract/MED/21341332
Apr 01, 2011 · In this Concept, we will focus on the localized delivery of siRNA to a target site using various delivery modalities. In certain tissues, such as the eye, central nervous system and lung, it has been demonstrated that a simple injection of naked siRNA will silence gene expression specifically in …Author: Melissa D. Krebs, Eben Alsberg
https://pubs.acs.org/doi/abs/10.1021/ja9037615
In this work a new paradigm is presented that will allow for the localized delivery of siRNA that is controlled and sustained over time, thus allowing cells at the site of interest to be directly exposed to a gradual release of bioactive siRNA.Author: Melissa D. Krebs, Oju Jeon, Eben Alsberg
https://www.researchgate.net/publication/264302297_ChemInform_Abstract_Localized_Targeted_and_Sustained_siRNA_Delivery
ChemInform Abstract: Localized, Targeted, and Sustained siRNA Delivery Article in ChemInform 42(26) · June 2011 with 26 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508156/
For example, localized delivery would permit targeted siRNA exposure to non-malignant tumors or sites of tumor resection, which may lower the dose required for efficacy and potentially reduce effects on non-target cells . siRNA delivery at a specific location in the body may also permit regulation of transplanted or host cell gene expression to ...Author: Khanh Nguyen, Phuong Ngoc Dang, Eben Alsberg
https://www.deepdyve.com/lp/wiley/localized-targeted-and-sustained-sirna-delivery-lALLXiRZVb
Jul 07, 2011 · Localized, Targeted, and Sustained siRNA Delivery Localized, Targeted, and Sustained siRNA Delivery Krebs, Melissa D.; Alsberg, Eben 2011-07-07 00:00:00 Short interfering RNA (siRNA) functions directly in the cytoplasm, where it is assembled into an RNA‐induced silencing complex (RISC). The localized delivery of siRNA to a specific site in vivo is highly challenging.
https://www.academia.edu/27908384/ChemInform_Abstract_Localized_Targeted_and_Sustained_siRNA_Delivery
ChemInform Abstract: Localized, Targeted, and Sustained siRNA Delivery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873513/
Jun 25, 2013 · The nano-layered siRNA dressings presented in this work demonstrate a truly effective method for the incorporation and localized delivery of siRNA for sustained time periods; the knockdown period and efficacy surpass many other surface-based localized release systems for RNAi.Author: Steven Castleberry, Mary Wang, Paula T. Hammond
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