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https://pubs.acs.org/doi/10.1021/bc060367e
We have applied these principles to the delivery of small interfering RNA (siRNA) therapeutics, where systemic delivery is hampered by rapid excretion and nontargeted tissue distribution. Using a PEGlyated quantum dot (QD) core as a scaffold, siRNA and tumor-homing peptides (F3) were conjugated to functional groups on the particle's surface.Author: Austin M. Derfus, Alice A. Chen, Dal-Hee Min, Erkki Ruoslahti, Sangeeta N. Bhatia
https://pubs.acs.org/doi/10.1021/ja800086u
We report the rational design of multifunctional nanoparticles for short-interfering RNA (siRNA) delivery and imaging based on the use of semiconductor quantum dots (QDs) and proton-absorbing polymeric coatings (proton sponges).Author: Maksym V. Yezhelyev, Lifeng Qi, Ruth M. O'Regan, Shuming Nie, Xiaohu Gao
https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.13841
Confocal microscopy evidence for delivery of siRNA conjugated JB577 QD into cytosol. (a) Cells were transfected with polyethylene glycol (PEG) QD‐JB577‐siRNA constructs for 24 h, siRNA was labeled with Cy3 (green), quantum dots are shown as red and nuclei stained with …Author: Ted Getz, Jingdong Qin, Igor L. Medintz, James B. Delehanty, Kimihiro Susumu, Philip E. Dawson, Glyn...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30074-9
Jan 01, 2012 · Delivery of Quantum Dot-siRNA Nanoplexes in SK-N-SH Cells for BACE1 Gene Silencing and Intracellular Imaging. Shengliang Li. Shengliang Li. Affiliations. Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Search for articles by this author.Author: Shengliang Li, Zhonghua Liu, Fengtao Ji, Zijian Xiao, Minjuan Wang, Yingji Peng, Yulin Zhang, Ling L...
https://www.sciencedirect.com/science/article/pii/S1001841717302486
Quantum dot-mediated siRNA theranostic systems enhance the siRNA delivery, and track the uptake and distribution of siRNA. Previous article in issue Next article in issueAuthor: Zhi-Yao He, Zhao-Hui Jin, Mei Zhan, Zhou Qin, Zhi Li, Ting Xu
https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb01068k
In this study, we reported the engineering of polyelectrolyte polymers coated BP quantum dots (BP-QDs)-based nanocarriers to deliver small interfering RNA (siRNA) into human ovarian teratocarcinoma PA-1 cells. Compared to the commercial delivery reagents, …Author: Feng Yin, Kuan Hu, Si Chen, Dongyuan Wang, Jianing Zhang, Mingsheng Xie, Dan Yang, Meng Qiu, Han Zha...
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