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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
https://www.ncbi.nlm.nih.gov/pubmed/29277310
Feb 15, 2018 · The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves. The purpose of this review is to describe the details of this mechanism to better direct future research.Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
https://www.nature.com/articles/nb.1866
Jun 07, 2011 · Intranasal drug administration has also been used to deliver peptide hormones to regulate enuresis 6 and renal colic 7. Several factors are thought to influence drug uptake into the brain …Author: Robert I Henkin
https://www.sciencedirect.com/science/article/pii/S002432051730663X
Review article Mechanism of intranasal drug delivery directly to the brain 1. Introduction. The last decade has seen an increase in the prevalence... 2. Anatomy. The nose is responsible for olfaction and respiration. 3. Transport mechanisms. The movement of molecules from the nasal cavity to the ...Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
Intranasal delivery of therapeutics involves spraying therapeutics into the upper part of the nasal cavity to enable them to follow these olfactory axon bundles directly into the brain through foramena in the cribriform plate. Once across the cribriform plate,...
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The concentration of drug, dose, and volume of dose administered are all important factors that can affect nasal drug delivery to the brain. Nasal drug absorption increases as the concentration of drug increases at the site of administration.
https://www.youtube.com/watch?v=q6uCIgWQkwM
Feb 06, 2017 · Direct transport of drug through nose to brain by passing BBB. ... Intranasal (nose to brain) drug delivery system Sagar Savale. ... INTRANASAL DRUG DELIVERY TO BRAIN - Duration: ...Author: Sagar Savale
https://www.mdpi.com/1999-4923/12/3/251/htm
Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver drugs to the brain bypassing the blood-brain barrier (BBB). This study aimed at preparing and characterizing an innovative composite formulation, associating the liposome and hydrogel approaches, suitable for intranasal administration. Thermosensitive gel formulations were obtained based on a mixture ...
http://intranasal.net/Peer%20Reviewed%20literature/Talegaonkar,%20Intranasal%20delivery%20-%20An%20approach%20to%20bypass%20the%20blood%20brain%20barrier,%20I%20J%20Pharm%202004.pdf
Intranasal delivery: An approach to bypass the blood brain barrier S. Talegaonkar, P. R. Mishra ABSTRACT The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Transmucosal delivery of drugs through olfactory or trigeminal pathways to brain bypassing the BBB is referred as the direct IN drug transportation to brain. This is the only route through which brain is in connection with the outside environment ( Mistry et al., 2009 ).Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
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