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https://www.mdpi.com/journal/pharmaceutics/special_issues/biological_barriers
Since the majority of drug candidates fail in pre- and clinical trials, due largely to bioavailability pitfalls, the use of polymeric nanoparticles (NPs) as drug delivery systems has been reported as an interesting tool to increase the stealth capacity of drugs or help drug candidates to surpass biological barriers, among other benefits.
https://news.harvard.edu/gazette/story/2018/07/crossing-biological-barriers-for-better-drug-delivery/
Jul 17, 2018 · Many pharmaceutical drugs are small molecules taken orally as a pill or liquid, and are absorbed into the body through the gut. The drug landscape, however, is beginning to shift to biological products such as vaccines, gene therapies, and recombinant proteins,...
http://www.nanomedicine.dtu.dk/Research/Biological-barriers.aspx
Apr 28, 2015 · Biological barriers. A major challenge in the drug delivery field is to enhance transport of therapeutics across biological barriers such as the blood brain barrier (BBB), the small intestine, nasal, skin and the mouth mucosa. These barriers are designed by nature to keep foreign material out and only allow small molecules with specific...
https://www.sciencedirect.com/science/article/pii/S0168365919303153
Review article Crossing biological barriers with nanogels to improve drug delivery performance 1. Introduction. Issues like multidrug resistance developed by cancer cells and bacteria,... 2. Nanogels overcoming biological barriers. 3. The mucus gel barrier: problems and strategies. 4. The skin ...Author: Julio César Cuggino, Julio César Cuggino, Ernesto Rafael Osorio Blanco, Ernesto Rafael Osorio Blanco...
https://www.nature.com/articles/nbt.3330
Sep 08, 2015 · Biological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation.Author: Elvin Blanco, Haifa Shen, Haifa Shen, Mauro Ferrari, Mauro Ferrari
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