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https://www.doctorabel.us/cell-therapy/iv-extracellular-barriers-for-gene-delivery.html
Sep 17, 2018 · Extracellular Barriers For Gene Delivery. For in vivo applications, the development of polyplexes is not only confronted with intracellular barriers, but also with extra cellular barriers, which are those prior to reaching the target cells.
https://www.atsjournals.org/doi/pdf/10.1513/pats.200403-024MS
of barriers exist that restrict exogenous gene delivery to the airway epithelium by commonly used viral vectors. Components of the innate and cell-mediated immune system collectively limit both the access to and duration of gene transfer vectors to the airway epithelium.Alternativeviralvectorsthathaveevolvedtocircumvent
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · This Review introduces the biological barriers to gene deliveryin vivoand discusses recent advances in material sciences, nanotechnology …Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.ncbi.nlm.nih.gov/pubmed/12532370
For the small fraction of material that is able to escape this vesicular trafficking pathway, the cytosol provides additional physical and metabolic barriers to further trafficking to the nucleus. Finally, nuclear uptake has been demonstrated to be a significant barrier to gene delivery.Author: Christopher M. Wiethoff, C.Russell Middaugh
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/cancer-gene-therapy-key-biological-concepts-in-the-design-of-multifunctional-non-viral-delivery-syst
The most fundamental barrier that the human body possesses is its skin. The stratum corneum is the skin’s outermost layer, and provides an imposing barrier to gene delivery [30]; the densely packed cornified cells of this layer protect the body from a range of foreign material.Author: Cian M. McCrudden, Helen O. McCarthy
https://www.sciencedirect.com/science/article/pii/S0378517301008614
For gene expression to occur genes must be transported to the interior of the cell nucleus and a number of biological barriers to effective gene delivery have been identified. These may be divided into extracellular such as the targeting barrier mentioned above and intracellular such as the need for endosomal escape after endocytosis and the inefficient trafficking of genes to the nucleus.Author: Maureen D. Brown, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.intechopen.com/books/novel-gene-therapy-approaches/extracellular-and-intracellular-barriers-to-non-viral-gene-transfer
Gene delivery vectors that utilize endocytosis to access the cytoplasm are then moved through the endocytic compartment. Thus, another major barrier to successful gene delivery is the release of the DNA from the endosome before it is degraded at the lysosomal level.Author: Lynn F. Gottfried, David A. Dean
http://www.nanomedicine.dtu.dk/Research/Biological-barriers.aspx
Apr 28, 2015 · Biological barriers. A major challenge in the drug delivery field is to enhance transport of therapeutics across biological barriers such as the blood brain barrier (BBB), the small intestine, nasal, skin and the mouth mucosa. These barriers are designed by nature to keep foreign material out and only allow small molecules with specific...
https://www.sciencedirect.com/science/article/pii/B9780123849649000025
After the endosomal escape, cytoplasm provides additional physical and metabolic barriers to further trafficking of all genetic material to the nucleus except silencing genes. Nuclear uptake for efficient transgene expression is the most significant barrier to gene delivery.Author: Kaustubh Anil Jinturkar, Ambikanandan Misra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978509/
Given its ability to negotiate several distinct biological barriers, including proper protection of cargo, margination to endothelial walls 43, accumulation at disease sites 46 and controlled release of cargo, the multistage delivery approach has been applied primarily toward chemotherapeutic applications and also shows potential in RNA interference (RNAi) strategies in mouse models of ovarian 47 and breast …Author: Elvin Blanco, Haifa Shen, Haifa Shen, Mauro Ferrari, Mauro Ferrari
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