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https://www.researchgate.net/publication/7270727_Intranasal_delivery_of_vaccines_against_HIV
As the protection against HIV may require both cytotoxic T cell and antibodies, a combination of adjuvants/delivery systems for combinations of mucosal and parenteral immunisations may be required ...
https://www.ncbi.nlm.nih.gov/pubmed/26824411
Mar 07, 2016 · Intranasal vaccination not only stimulates systemic immunity but also elicits mucosal immunity that provides first defense for mucosally transmitted diseases like HIV-1. Adjuvants such as TLR agonists are usually codelivered with antigens to enhance the immunogenicity of vaccines.Author: Man Li, Yuhong Jiang, Tao Gong, Zhirong Zhang, Xun Sun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810059/
Further, intranasal vaccination with an adenoviral vector expressing OVA or HIV-1 envelope was as effective as intramuscular vaccination for generating OVA- or ENV-specific immunity in the FRT.Author: Shailbala Singh, Kimberly S. Schluns, Guojun Yang, Scott M. Anthony, Scott M. Anthony, Michael A. Ba...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539070/
Jul 12, 2012 · Intranasal delivery of the cationic PLGA particles containing FMDV DNA vaccine formulations enhanced protective immunity against FMDV . Whilst DNA vaccines have been shown promise for intranasal vaccine delivery, the technology requires further research to develop effective vaccines …Author: Mehfuz Zaman, Saranya Chandrudu, Istvan Toth
https://www.mdpi.com/1999-4923/6/3/378/pdf
present. Furthermore, intranasal delivery is a needle-free, non-invasive route of administration with the possibility of self-administration. Intranasal DNA vaccination has become a promising approach in offering immune protection against various pathogens that affect the respiratory system includingAuthor: Yingying Xu, Pak-Wai Yuen, Jenny Ka-Wing Lam
https://www.mdpi.com/1999-4923/6/3/378/htm
Intranasal delivery of DNA vaccines has become a popular research area recently. It offers some distinguished advantages over parenteral and other routes of vaccine administration. Nasal mucosa as site of vaccine administration can stimulate respiratory mucosal immunity by interacting with the nasopharyngeal-associated lymphoid tissues (NALT).Author: Yingying Xu, Pak-Wai Yuen, Jenny Ka-Wing Lam
https://www.sciencedirect.com/science/article/pii/B9780323399814000154
The mucosal surfaces represent the major site of entry of many pathogens, and major challenges in vaccine development include safety and stability in a suitable dosage form. Micro- and nanocarrier-based delivery systems as nasal vaccines induce humoral, cellular, and mucosal immunity.Author: M. Ramvikas, M. Arumugam, S.R. Chakrabarti, K.S. Jaganathan
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