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https://www.researchgate.net/publication/51171781_Intranasal_delivery_of_therapeutic_proteins_for_neurological_diseases
Intranasal delivery of therapeutic proteins for neurological diseases Article · Literature Review in Expert Opinion on Drug Delivery 8(10):1277-96 · May 2011 with 41 Reads How we measure 'reads'
https://www.tandfonline.com/doi/abs/10.1517/17425247.2011.588204
Aug 12, 2015 · Introduction: Among the range of therapeutic protein candidates for new generation treatments of neurological diseases, neurotrophic factors and recombinant antibodies hold the greatest potential. However, major difficulties in their safe and effective delivery to the brain severely limit these applications. The BBB restricts the exchange of proteins between the plasma and the CNS.Author: Francesca Malerba, Francesca Paoletti, Simona Capsoni, Antonino Cattaneo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476983/
Mar 24, 2015 · TARGETING PROTEINS AND PEPTIDES TO SPECIFIC REGIONS OF THE BRAIN TO ENHANCE THERAPEUTIC PROPERTIES. Intranasal delivery of proteins and peptides to the CNS provides a means to bypass the BBB in the treatment of neurodegenerative diseases like …Author: M. Elizabeth Meredith, Therese S. Salameh, William A. Banks
https://core.ac.uk/display/80194409
Intranasal delivery of therapeutic proteins for neurological diseases . By Malerba F, Paoletti F, Capsoni S and Cattaneo A. Abstract. INTRODUCTION: Among the range of therapeutic protein candidates for new generation treatments of neurological diseases, neurotrophic factors and recombinant antibodies hold the greatest potential. However, major ...Author: Francesca Malerba, Francesca Paoletti, Simona Capsoni, Antonino Cattaneo
https://www.springer.com/gp/book/9783030167134
In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · N2B delivery of therapeutic agents is a future perspective to treat neurological diseases. To successfully create N2B delivery systems one has to understand the unique structure of the olfactory region. The use of N2B delivery mechanism in drug application has some advantages over strategies that aim to cross the blood-brain barrier.Author: Stella Gänger, Katharina Schindowski
http://intranasal.net/Peer%20Reviewed%20literature/Ying,%20NOse-brain%20path%20and%20neurologic%20diseases,%20Future%20medicine.pdf
of intranasal drug delivery for treating various CNS diseases. ‘Understanding of the direct nose-to-brain routes may also promote our understanding of the pathogenic mechanisms of neurological diseases.’ Future perspective. Although major progress has been made regard-ing …
https://www.sciencedirect.com/science/article/pii/S0022354916304841
The blood–brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS), posing a significant challenge to drug development efforts to treat neurological and psychiatric diseases and disorders. Intranasal delivery is a noninvasive and convenient method that rapidly targets ...Author: Shyeilla V. Dhuria, Shyeilla V. Dhuria, Leah R. Hanson, William H. Frey, William H. Frey
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Particulate delivery systems are proven efficient carriers for vaccine delivery , and the most frequently used systems are lipoplex , and liposomes , , , . While these lipid-based nano carriers can deliver mRNA efficiently, the epithelial barrier remains a challenge to intranasal delivery of mRNA vaccines.Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
https://www.researchgate.net/publication/274086704_Intranasal_Delivery_of_Proteins_and_Peptides_in_the_Treatment_of_Neurodegenerative_Diseases
Intranasal delivery of drugs, peptides, and other proteins could be very useful in the future for the prevention or treatment of brain related diseases. Discover the world's research 16+ million ...
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