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https://www.nature.com/articles/nm1385
Apr 09, 2006 · Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation Skip to …Author: Je Min Choi, Mi Hyun Ahn, Wook Jin Chae, Yung Gook Jung, Jae Chul Park, Hyun Mi Song, Young Eun Kim,...
https://www.researchgate.net/profile/Eddie_Chae2/publication/7176022_Intranasal_delivery_of_the_cytoplasmic_domain_of_CTLA-4_using_a_novel_protein_transduction_domain_prevents_allergic_inflammation/links/596a4532aca2728ca681dfea/Intranasal-delivery-of-the-cytoplasmic-domain-of-CTLA-4-using-a-novel-protein-transduction-domain-prevents-allergic-inflammation.pdf
Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation
https://www.researchgate.net/publication/7176022_Intranasal_delivery_of_the_cytoplasmic_domain_of_CTLA-4_using_a_novel_protein_transduction_domain_prevents_allergic_inflammation
Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation
https://www.nature.com/articles/emm2017107
Aug 04, 2017 · In this study, we hypothesized that dNP2 could efficiently deliver a protein to asthmatic lung resident cells via intranasal administration and that dNP2-ctCTLA-4 could regulate Th2 inflammation. We analyzed the efficiency of dNP2 and Hph-1 with respect to intranasal protein delivery.Author: Sangho Lim, Sangho Lim, Jung Ho Sohn, Jung Ho Sohn, Ja Hyun Koo, Ja Hyun Koo, Jung Won Park, Je Min ...
https://scholar.google.com/scholar_lookup?title=Intranasal%20delivery%20of%20the%20cytoplasmic%20domain%20of%20CTLA-4%20using%20a%20novel%20protein%20transduction%20domain%20prevents%20allergic%20inflammation&publication_year=2006&author=J.M.%20Choi&author=M.H.%20Ahn&author=W.J.%20Chae&author=Y.G.%20Jung&author=J.C.%20Park&author=H.M.%20Song&author=Y.E.%20Kim&author=J.A.%20Shin&author=C.S.%20Park&author=J.W.%20Park&author=T.K.%20Park&author=J.H.%20Lee&author=B.F.%20Seo&author=K.D.%20Kim&author=E.S.%20Kim&author=D.H.%20Lee&author=S.K.%20Lee
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https://www.pnas.org/content/105/50/19875
Dec 16, 2008 · CTLA-4 (CD152) negatively regulates T cell activation signaling, and the cytoplasmic domain of CTLA-4 (ctCTLA-4) itself has the capacity to inhibit T cell activation in vitro and in vivo . In this study, the inhibitory mechanisms of the cell-permeable recombinant protein Hph-1-ctCTLA-4 on T cell activation and its ability to prevent collagen-induced arthritis were analyzed.Author: Je Min Choi, Seung Hyung Kim, Jae Hoon Shin, Thomas Gibson, Byoung Seok Yoon, Dong Ho Lee, Seung Kyo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604944/
Dec 16, 2008 · CTLA-4 (CD152) negatively regulates T cell activation signaling, and the cytoplasmic domain of CTLA-4 (ctCTLA-4) itself has the capacity to inhibit T cell activation in vitro and in vivo. In this study, the inhibitory mechanisms of the cell-permeable recombinant protein Hph-1-ctCTLA-4 on T cell activation and its ability to prevent collagen-induced arthritis were analyzed.Author: Je Min Choi, Seung Hyung Kim, Jae Hoon Shin, Thomas Gibson, Byoung Seok Yoon, Dong Ho Lee, Seung Kyo...
https://www.pnas.org/content/pnas/105/50/19875.full.pdf
airway inflammation via an intranasal route (25). In this study, we describe possible mechanisms for the inhibitory function of the cell-permeable cytoplasmic domain of CTLA-4 (Hph-1-ctCTLA-4) in T cell activation and the therapeutic effects via systemic or transdermal application in the collagen type II (CII)-induced arthritis (CIA) model in ...Author: Je Min Choi, Seung Hyung Kim, Jae Hoon Shin, Thomas Gibson, Byoung Seok Yoon, Dong Ho Lee, Seung Kyo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559193/
Jan 22, 2013 · CTLA-4-deficient mice undergo a massive, CD28-dependent expansion of autoreactive T cells in lymph nodes, spleen, and several peripheral organs. These mice die in less than 4 weeks post-birth due to diffuse lymphoproliferative disease (41, 42) but can be rescued from lethality by exogenous expression of the CTLA-4 extracellular domain .Author: Joseph F. Grosso, Maria N. Jure-Kunkel
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Moreover, good colloidal stability and mucus-binding ability are vital for intranasal drug delivery systems . The longer nasal residence time of our mRNA vaccine may also reduce the risk that antigen is delivered to the lung or the central nervous system, reducing clearance and …Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
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