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https://www.researchgate.net/publication/6355540_Intranasal_Delivery_Physicochemical_and_Therapeutic_Aspects
The current review provides an in-depth discussion of therapeutic aspects of IN delivery including consideration of the intended indication, regimen, and patient population, as well as physicochemical properties of the drug itself.
https://www.deepdyve.com/lp/elsevier/intranasal-delivery-physicochemical-and-therapeutic-aspects-faJtJvtLPA
Jun 07, 2007 · Intranasal delivery: Physicochemical and therapeutic aspects The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid drug onset, potential for central nervous system delivery, and no first-pass metabolism.
https://www.ncbi.nlm.nih.gov/pubmed/22465159
Intranasal administration is a non-invasive route for drug delivery, which is widely used for the local treatment of rhinitis or nasal polyposis. Since drugs can be absorbed into the systemic circulation through the nasal mucosa, this route may also be used in a range of acute or chronic conditions requiring considerable systemic exposure.Author: Stanislas Grassin-Delyle, Amparo Buenestado, Emmanuel Naline, Christophe Faisy, Sabine Blouquit-Laye...
https://www.future-science.com/doi/full/10.4155/tde-2018-0002
There are several unresolved issues regarding nasal spray formulation and volume that may contribute to conflicting intranasal oxytocin clinical trial data. For instance, nasal spray physicochemical properties such as viscosity , liposolubility, and ionasation , have been shown to impact spray deposition and uptake. The physicochemical properties of oxytocin and its nasal spray excipients are not …Author: Daniel S Quintana, Knut T Smerud, Ole A Andreassen, Per G Djupesland
https://www.ncbi.nlm.nih.gov/pubmed/20067706
Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased.Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action.Author: Anaísa Pires, Ana Fortuna, Gilberto Alves, Amílcar Falcão
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · 6.3. Intranasal Medical Drug Delivery Devices. Nasal pump sprays and droppers are most likely the best-known nasal medical devices, but they are limited to liquid-or lipid-based formulations. But even if different application methods, as changing of the head position were used, the intranasally applied liquids do hardly reach the olfactory cleft.Author: Stella Gänger, Katharina Schindowski
https://www.sciencedirect.com/science/article/pii/S002839081830282X
Several studies using experimental stroke models have shown the therapeutic potential of intranasal delivery of a wide range of compounds of different sizes (Chen et al., 2012). Thus, the intranasal administration of an inhibitor of caspase 9 has been shown to reduce the loss of neurons and neurological deficits ( Akpan et al., 2011 ).Author: Rachida Guennoun, Magalie Fréchou, Pauline Gaignard, Philippe Liere, Abdelhamid Slama, Michael Schum...
http://intranasal.net/DeliveryTechniques/default.htm
A second method of intranasal drug delivery is to take a solubilized medication (liquid form) and drip it into the nose a few drops at a time, allowing it to run down onto the nasal mucosa. This can be done using a syringe or in some instances using the packaged form …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287299/
Nov 15, 2014 · The physicochemical properties and formulation aspects necessary for oral delivery are mainly driven by the gastrointestinal barrier biology, and drug substance and product quality concerns. They can therefore be viewed as similar among small molecules and peptides and have been reviewed elsewhere . Accordingly, the criteria for oral delivery encompass five categories: (1) physicochemical properties…Author: Annette Bak, Dennis Leung, Stephanie E. Barrett, Seth Forster, Ellen C. Minnihan, Andrew W. Leithead...
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